Results 111 to 120 of about 11,777 (218)
The FASEB Journal, Volume 39, Issue 24, 31 December 2025.We investigated two models of mitochondrial dysfunction in podocytes, using two cell culture models: podocytes isolated from mice with Oma1 deletion (Oma1del) and mouse podocytes modified with an inducible knockdown of PHB2 (Phb2kd). OMA1 deficiency induced a glycolytic shift, enhanced glutamine anaplerosis, and sustained energy homeostasis after ...
Cem Özel +13 more
wiley +1 more source
Methionine adenosyltransferases in liver cancer. [PDF]
, 2019 Methionine adenosyltransferases (MATs) are essential enzymes for life as they produce S-adenosylmethionine (SAMe), the biological methyl donor required for a plethora of reactions within the cell.
Barbier-Torres, Lucia +4 more
core
The emerging roles of prohibitins in folliculogenesis
Frontiers in Bioscience, 2012 Prohibitins are members of a highly conserved eukaryotic protein family containing the stomatin/prohibitin/flotillin/HflK/C (SPFH) domain (also known as the prohibitin (PHB) domain) found in divergent species from prokaryotes to eukaryotes. Prohibitins are found in unicellular eukaryotes, fungi, plants, animals and humans.
Indrajit, Chowdhury +5 more
openaire +2 more sources
Advanced Materials, Volume 37, Issue 49, December 10, 2025.Adipocyte membrane‐coated nanoparticles loaded with rosiglitazone in hydrogel offer an alternative approach to conventional obesity treatments. This system selectively targets adipocytes, inducing lipolysis by activating chaperone‐mediated autophagy through mild photothermal stimulation.
Jaehyun Choi +8 more
wiley +1 more source
A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation [PDF]
, 2016 We previously described diaryl trifluorothiazoline compound 1a (hereafter referred to as fluorizoline) as a first-in-class small molecule that induces p53-independent apoptosis in a wide range of tumor cell lines.
Albericio Palomera, Fernando +15 more
core +1 more source
Opposing function of mitochondrial prohibitin in aging
Aging, 2010 While specific signalling cascades involved in aging, such as the insulin/IGF-1 pathway, are well-described, the actual metabolic changes they elicit to prolong lifespan remain obscure. Nevertheless, the tuning of cellular metabolism towards maximal survival is the molecular basis of longevity.
Artal-Sanz, Marta +1 more
openaire +4 more sources
Nanomedicines Against Mitochondrial Dysfunction‐Induced Metabolic Diseases
Advanced Science, Volume 12, Issue 48, December 29, 2025.Mitochondrial dysfunction is central to metabolic diseases. Nanomedicine offers transformative approaches for restoring function via targeted delivery, responsive release, and multimodal therapy. This review outlines the pathological basis, nanocarrier design, organelle‐specific targeting, recent advances, and future clinical translation challenges ...
Ke Xu +9 more
wiley +1 more source
MedComm, Volume 6, Issue 12, December 2025.Alcohol‐related (ALD) and metabolic dysfunction‐associated (MASLD) steatotic liver disease, while initiated by distinct etiologies (ethanol vs. metabolic stress), converge on shared core pathogenic pathways that drive progression. These include dysregulated lipid metabolism, programmed cell death, cellular senescence, gut dysbiosis, and immune ...
Yupin Tan +3 more
wiley +1 more source
Gene expression patterns in heterozygous Plk4 murine embryonic fibroblasts [PDF]
, 2009 The polo-like kinases (Plks) are a group of serine/threonine kinases which have roles in many aspects of cellular function including the regulation of mitotic activity and cellular stress responses.
Alan Morettin +3 more
core +3 more sources
Prohibitins: A Critical Role in Mitochondrial Functions and Implication in Diseases
Cells, 2019 Prohibitin 1 (PHB1) and prohibitin 2 (PHB2) are proteins that are ubiquitously expressed, and are present in the nucleus, cytosol, and mitochondria.
Anna Signorile +3 more
doaj +1 more source