Parasites & Vectors, 2018 Background Leishmaniasis, a disease caused by parasites of the genus Leishmania, infects roughly 12 million people worldwide, with about two million new cases per year. Prohibitins (PHBs) are highly conserved proteins belonging to the stomatin-prohibitin
Teresa Cruz-Bustos +4 more
doaj +1 more source
A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. [PDF]
, 2011 To broadly explore mitochondrial structure and function as well as the communication of mitochondria with other cellular pathways, we constructed a quantitative, high-density genetic interaction map (the MITO-MAP) in Saccharomyces cerevisiae.
Cassidy-Stone, Ann +9 more
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Prohibitin overexpression improves myocardial function in diabetic cardiomyopathy
Oncotarget, 2015 Prohibitin (PHB) is a highly conserved protein implicated in various cellular functions including proliferation, apoptosis, tumor suppression, transcription, and mitochondrial protein folding. However, its function in diabetic cardiomyopathy (DCM) is still unclear.
Wen-qian, Dong +10 more
openaire +3 more sources
Molecular implications of prohibitin-1 deficiency in liver homeostasis [PDF]
, 2011 Comunicaciones a ...
Bigaud, Emilie +3 more
core
Circulating microRNAs as potential new biomarkers for prostate cancer [PDF]
, 2013 Since they were first described in the 1990s, circulating microRNAs (miRNAs) have provided an active and rapidly evolving area of current research that has the potential to transform cancer diagnostics and therapeutics.
Bevan, CL +3 more
core +1 more source
PLoS Genetics, 2012 Fusion and fission of mitochondria maintain the functional integrity of mitochondria and protect against neurodegeneration, but how mitochondrial dysfunctions trigger neuronal loss remains ill-defined.
Carsten Merkwirth +7 more
doaj +1 more source
Antiandrogens Act as Selective Androgen Receptor Modulators at the Proteome Level in Prostate Cancer Cells* [PDF]
, 2015 Current therapies for prostate cancer include antiandrogens, inhibitory ligands of the androgen receptor, which repress androgen-stimulated growth. These include the selective androgen receptor modulators cyproterone acetate and hydroxyflutamide and the ...
Begum, Shajna +11 more
core +2 more sources
Molecular characterization of a gene induced during wheat hypersensitive reaction to stripe rust
Biologia Plantarum, 2011 A novel gene induced during hypersensitive reaction (HIR) in wheat was identified using in silico cloning and designated as TaHIR2. The TaHIR2 gene was deduced to encode a 284-amino acid protein, whose molecular mass and isoelectric point (pI) were 31.05
G. Zhang +9 more
doaj +1 more source
Poplar woody root proteome during the transition dormancy-active growth [PDF]
, 2013 Woody plants living in temperate climates finely regulate their growth and development in relation to seasonal changes; their transition from vegetative to dormancy phase represents an adaptation to their environment. Events occurring in the shoot during
Chiatante, D. +8 more
core +1 more source
Stomatin-like Protein 2 Links Mitochondria to T-Cell Receptor Signalosomes at the Immunological Synapse and Enhances T-Cell Activation [PDF]
, 2007 T cell activation through the antigen receptor (TCR) requires sustained signalling from microclusters in the peripheral region of the immunological synapse (IS).
Caitlin D. Lemke +10 more
core +1 more source