Results 191 to 200 of about 11,901 (220)

Prohibitin in Adipose and Immune Functions

Trends in Endocrinology & Metabolism, 2016
Prohibitin (PHB) was discovered in a quest to find genes with antiproliferative functions. However, the attribute of PHB that is responsible for its antiproliferative function remains elusive. Meanwhile, recent studies have established PHB as a pleiotropic protein with roles in metabolism, immunity, and senescence.
Sudharsana R, Ande, K Hoa, Nguyen, B L Grégoire, Nyomba, Suresh, Mishra   +3 more
openaire   +2 more sources

Prohibitins in infection: potential therapeutic targets

Future Microbiology
Prohibitins (PHBs) are members of a highly conserved family of proteins, including prohibitin1 and prohibitin2. These proteins are predominantly localized in mitochondria, the nucleus, and cell membranes, where they play critical roles in mitochondrial biogenesis, apoptosis, immune regulation, and other biological processes.
Nuo, Chen, Xiaolan, Liu, Lulu, Wang, Hui, Yu, Fangqian, Liu, Mengran, Yuan, Qimeng, Wang, Tianyi, Zhang, Xiaoxiang, Zhou, Hua, Wang, Zengjun, Ji, Hongxing, Shen   +11 more
openaire   +2 more sources

Prohibitin: a potential target for new therapeutics

Trends in Molecular Medicine, 2005
Prohibitin (PHB) is localized to the mitochondria where it might have a role in the maintenance of mitochondrial function and protection against senescence. There is considerable controversy concerning the function of nuclear-localized PHB. PHB has potential roles as a tumor suppressor, an anti-proliferative protein, a regulator of cell-cycle ...
Suresh, Mishra, Leigh C, Murphy, B L Gregoire, Nyomba, Liam J, Murphy   +3 more
openaire   +2 more sources

Prohibitin Signaling at the Kidney Filtration Barrier

2017
The kidney filtration barrier consists of three well-defined anatomic layers comprising a fenestrated endothelium, the glomerular basement membrane (GBM) and glomerular epithelial cells, the podocytes. Podocytes are post-mitotic and terminally differentiated cells with primary and secondary processes.
Christina, Ising, Paul T, Brinkkoetter
openaire   +2 more sources

Prohibitin is involved in mitochondrial biogenesis in plants

The Plant Journal, 2006
SummaryProhibitin, which consists of two subunits PHB1 and PHB2, plays a role in cell‐cycle progression, senescence, apoptosis, and maintenance of mitochondrial function in mammals and yeast. In this study, we examined the role of prohibitins in plants by using virus‐induced gene silencing (VIGS) of two prohibitin subunit genes of Nicotiana benthamiana,
Chang Sook, Ahn, Jeong Hee, Lee, A, Reum Hwang, Woo Taek, Kim, Hyun-Sook, Pai   +4 more
openaire   +2 more sources

Prohibitin has an important role in adipocyte differentiation

International Journal of Obesity, 2011
To investigate whether prohibitin (PHB) is a target gene in adipocyte differentiation and modulates insulin-induced adipocyte differentiation.3T3-L1 preadipocyte overexpressing wild-type PHB and PHB mutant (lacking tyrosine-114 phosphorylation site) with or without insulin.The treatment of 3T3-L1 fibroblasts with insulin or peroxisome proliferator ...
S R, Ande, Z, Xu, Y, Gu, S, Mishra
openaire   +2 more sources

Prohibitin: Mitochondrial Tumor Suppressor Protein

1998
The prohibitin story begins with the development of an assay for the detection of mRNAs that could inhibit the initiation of DNA synthesis.1’2 Messenger RNAs were tested by microinjecting them into individual human diploid fibroblasts that had been growth-arrested by serum restriction.
openaire   +1 more source

Expression of prohibitin, an antiproliferative protein

Experimental Gerontology, 1992
J K, McClung, R L, King, L S, Walker, D B, Danner, M J, Nuell, C A, Stewart, R T, Dell'Orco   +6 more
openaire   +2 more sources

Mitochondrial dysfunction during loss of prohibitin 1 triggers Paneth cell defects and ileitis

Gut, 2020
Brandi L Cantarel, Themistocles Dassopoulos, Linda A Feagins   +2 more
exaly  

Prohibitin

2020
openaire   +1 more source