Results 91 to 100 of about 5,465,036 (281)

Proinflammatory Cytokines Dominate the Early Immune Response to Filarial Parasites [PDF]

The Journal of Immunology, 2003
Abstract Although the early human immune response to the infective-stage larvae (L3) of Brugia malayi has not been well-characterized in vivo (because of the inability to determine the precise time of infection), the consensus has been that it must involve a predominant Th2 environment.
Subash, Babu, Thomas B, Nutman
openaire   +2 more sources

Ultrathin Hydrogel Membranes Inspired by Soap Films Enable Physiologically Relevant Breathing Lung Models

Advanced Materials, EarlyView.
A soap‐film inspired strategy enables the fabrication of ultrathin yet robust GelMA‐PAAm membranes for breathing lung culture. The hydrogel membrane supports long‐term cyclic deformation under air‐liquid interface conditions, enabling physiologically relevant breathing motions of engineered lung tissue culture. ABSTRACT Breathing continuously stretches
Yunji Lee, Gwang Myeong Kim, Wookyeom Kim, Fenny Soetanto, Gyungin Ryu, Taehun Chung, Youn Soo Kim, Junmin Lee, Hwa‐Rim Lee, Sungjune Jung   +9 more
wiley   +1 more source

Some Aspects of Formation of a Systemic Inflammatory Response in Critically Ill Patients

Общая реаниматология, 2010
Objective: to study the general regularities and pathogenetic significance of changes in primary and secondary inflammatory mediator ratios in the formation of a systemic inflammatory response in critically ill patients. Subjects and methods.
I. M. Ustyantseva, O. I. Khokhlova, O. V., Petukhova, Yu. A. Zhevlakova, A. S. Kravtsova, K. V. Agadzhanyan   +5 more
doaj   +1 more source

Bacterial-epithelial contact is a key determinant of host innate immune responses to enteropathogenic and enteroaggregative escherichia coli [PDF]

, 2011
Background: Enteropathogenic (EPEC) and Enteroaggregative (EAEC) E. coli have similar, but distinct clinical symptoms and modes of pathogenesis. Nevertheless when they infect the gastrointestinal tract, it is thought that their flagellin causes IL-8 ...
Nigel J Klein, Simon H Murch, Edwards Lindsey A., Klein, Nigel J, Phillips, Alan D., Edwards, LA, Phillips, AD, Simon H. Murch, Edwards, Lindsey A., Phillips, Alan D, Mona Bajaj-Elliott, Lindsey A Edwards, Alan D. Phillips, Murch, SH, Bajaj-Elliott, Mona, Alan D Phillips, Klein Nigel J., Murch Simon H., Nigel J. Klein, Klein, NJ, Phillips Alan D., Klein, Nigel, Lindsey A. Edwards, Murch, Simon H, Bajaj-Elliott, M, Murch, Simon, Bajaj-Elliott Mona, Edwards, Lindsey A; id_orcid   +27 more
core   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

3D Printing of Soft Robotic Systems: Advances in Fabrication Strategies and Future Trends

Advanced Robotics Research, EarlyView.
Collectively, this review systematically examines 3D‐printed soft robotics, encompassing material selections, function integration, and manufacturing methodologies. Meanwhile, fabrication strategies are analyzed in order of increasing complexity, highlighting persistent challenges with proposed solutions.
Changjiang Liu, Bin Cui, Xumin Huang, Xiaoyu (Rayne) Zheng, T. Thang Vo‐Doan, Ruirui Qiao   +5 more
wiley   +1 more source

An unopposed proinflammatory response is beneficial for survival in the oldest old. Results of the Leiden 85-plus study

, 2011
The capacity to generate an efficient innate immune response is pivotal for survival. The objective of this study was to investigate innate immune function in relation to long-term survival in the oldest old.
Westendorp, Rudi G J, Maier, Andrea B., De Craen, Anton J M, Maier, Andrea B.; id_orcid, Van Den Biggelaar, Anita H J, Wijsman, Carolien A.   +5 more
core   +2 more sources

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Human intestinal epithelial and smooth muscle cells are potent producers of IL-6

Mediators of Inflammation, 2003
Background: Interleukin-6 (IL-6), a pluripotent cytokine, has traditionally been considered the product of proinflammatory cells. However, many other cell types have been shown to produce IL-6.
Edmond K. Ng, Ninder Panesar, Walter E. Longo, Marc J. Shapiro, Donald L. Kaminski, Kym C. Tolman, John E. Mazuski   +6 more
doaj   +1 more source

The biological response of macrophages to PMMA particles with different morphology and size

Biosurface and Biotribology, 2016
We used polymethylmethacrylate (PMMA) particles to investigate the relationship between particle properties and biological responses of macrophages.
R. Yoshioka, Y. Nakashima, Y. Fujiwara, Y. Komohara, M. Takeya, Y. Nakanishi   +5 more
doaj   +1 more source