Results 31 to 40 of about 636,811 (278)

Toward a Humanist and Agentic Paradigm of Inclusive Teaching—Lessons from the United States Civil Rights Era for College Pedagogy

Teaching & Learning Inquiry: The ISSOTL Journal
Inclusive teaching is a potentially transformative mindset and approach to reimagining education. To realize its full potential, we must be willing to redefine what it means to teach.
Bryan M. Dewsbury
doaj   +1 more source

Analysis of a Blended, In-Service, Continuing Education Course in a Public Health System: Lessons for Education Providers and Healthcare Managers

Frontiers in Public Health, 2020
Introduction: To train pharmacists working in the public health system, the Brazilian Ministry of Health developed a specialization course called Pharmaceutical Service and Access to Medicine Management (PSAMM) between 2010 and 2016.
Fernanda Manzini, Eliana Elisabeth Diehl, Mareni Rocha Farias, Mareni Rocha Farias, Rosana Isabel dos Santos, Luciano Soares, Norberto Rech, Norberto Rech, Andrigo Antonio Lorenzoni, Silvana Nair Leite, Silvana Nair Leite   +10 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Setting the scene and generating evidence for malaria elimination in Southern Mozambique

Malaria Journal, 2019
Mozambique has historically been one of the countries with the highest malaria burden in the world. Starting in the 1960s, malaria control efforts were intensified in the southern region of the country, especially in Maputo city and Maputo province, to ...
Pedro Aide, Baltazar Candrinho, Beatriz Galatas, Khátia Munguambe, Caterina Guinovart, Fabião Luis, Alfredo Mayor, Krijn Paaijmans, Lucía Fernández-Montoya, Laia Cirera, Quique Bassat, Sonia Mocumbi, Clara Menéndez, Delino Nhalungo, Ariel Nhacolo, Regina Rabinovich, Eusébio Macete, Pedro Alonso, Francisco Saúte   +18 more
doaj   +1 more source

Building institutional capacity for industrial symbiosis development : a case study of an industrial symbiosis coordination network in China [PDF]

, 2016
Recent research has examined how the concept of institutional capacity relates to the ability of organisations to deliver industrial symbiosis, and in particular how that ability itself can develop over time.
Chen, Yong, Deutz, Pauline, Wang, Qiaozhi   +2 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Implementation barriers and facilitators to a COVID-19 intervention in Bangladesh: The benefits of engaging the community for the delivery of the programme

BMC Health Services Research, 2022
Background BRAC (Bangladesh Rural Advancement Committee), the largest NGO globally, implemented a community-based comprehensive social behavior communication intervention to increase community resilience through prevention, protection, and care for COVID-
Fahmida Akter, Malika Tamim, Avijit Saha, Imran Ahmed Chowdhury, Omor Faruque, Animesh Talukder, Mohiuddin Ahsanul Kabir Chowdhury, Monzur Morshed Patwary, Albaab-Ur Rahman, Morseda Chowdhury, Malabika Sarker   +10 more
doaj   +1 more source

Department of Homeland Security Science and Technology Directorate: Developing Technology to Protect America [PDF]

, 2009
In response to a congressional mandate and in consultation with Department of Homeland Security's (DHS) Science and Technology Directorate (S&T), the National Academy conducted a review of S&T's effectiveness and efficiency in addressing homeland ...
Barry Bozeman, Caroline Purdy, Cindy L. Williams, David F. Garrison, Louise K. Comfort, Sally T. Hillsman   +5 more
core  

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source