Results 51 to 60 of about 113,296 (216)

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Community health and medical provision: impact on neonates (the CHAMPION trial)

BMC Pediatrics, 2007
Background The trial aims to evaluate whether neonatal mortality can be reduced through systemic changes to the provision and promotion of healthcare. Neonatal mortality rates in India are high compared to other low income countries, and there is a wide ...
Frost Chris, Jayanty Chitra, Figueiredo Ryan, Mukherjee Rohini, Mendiratta Tarana, Eble Alexander, Mann Vera, Boone Peter, Padmanabh M Reddy, Elbourne Diana   +9 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Paediatric Personalized Research Network Switzerland (SwissPedHealth): a joint paediatric national data stream

BMJ Open
Introduction Children represent a large and vulnerable patient group. However, the evidence base for most paediatric diagnostic and therapeutic procedures remains limited or is often inferred from adults.
, Julia A Bielicki, Luregn J Schlapbach, Klara Posfay-Barbe, Sven Schulzke, Martin Stocker, Anita Rauch, Christopher B Forrest, Effy Vayena, Claudia E Kuehni, Jacques Fellay, Philipp Latzin, Christian Kahlert, Seraina Prader, Ben D Spycher, Katrin Männik, Jana Pachlopnik Schmid, Klara M Posfay-Barbe, Roger Lauener, Keith Harshman, Kelly Ormond, Manon Jaboyedoff, Eric Giannoni, Tatjana Welzel, Dylan Lawless, Rebeca Mozun, Fabiën N Belle, Andrea Agostini, Matthias R Baumgartner, D Sean Froese, Sandra Goetze, Kathrin Hofmann, Aurélie Martin Necker, Patrick G A Pedrioli, Sven M Schulzke, Nicola Zamboni, Julia E Vogt, Audrey van Drogen, Aurélie Martin Necker, Cornelia Hagman, D Sean Froese, Daphné Chopard, Eirini I Petrou, Emanuele Palumbo, Ioannis Xenarios, Jana Pachlopnik Schmid, Léa Ho Dac, Lorenz M Leuenberger, Mariam Ait Oumelloul, Nicole Goebel, Simon Boutry, Thomas M Sutter, Varvara Dimopoulou, Vito RT Zanotelli, Xeni Deligianni, Xenia Bovermann, Yara Shoman, Anna Hartung   +57 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Production of Computing Technology in USSR: Outcomes of Implementation of Council of Ministers' Decree of December 30, 1967

Научный диалог
This article explores the implementation of decisions made by central party-state authorities at the turn of the 1960s and 1970s regarding a shift in policy towards the development and production of computing technology in the USSR.
E. V. Bodrova, V. V. Kalinov, V. N. Krasivskaya   +2 more
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

The clinical trial activation process: a case study of an Italian public hospital

Trials
Background/aims In order to make the centers more attractive to trial sponsors, in recent years, some research institutions around the world have pursued projects to reorganize the pathway of trial activation, developing new organizational models to ...
Carolina Pelazza, Marta Betti, Francesca Marengo, Annalisa Roveta, Antonio Maconi   +4 more
doaj   +1 more source