Results 41 to 50 of about 10,618,865 (261)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The 1st Evaluation Seminar of the National Project “Chance for Return 2”

Bratislava Law Review
On September 9, 2025, the 1st Evaluation Seminar of the national project Chance for Return 2 was held in Moyzes Hall, organised by the Corps of Prison and Court Guard in cooperation with the Faculty of Law of Comenius University Bratislava.
Jozef Čentéš, Jakub Ľorko
doaj   +1 more source

Towards a Collaborative National Research Data Management Network

International Journal of Digital Curation, 2016
This paper describes the plans and strategies to develop Portage, a national network of sustainable, shared services for research data management (RDM) in Canada. A description of the RDM context in Canada is provided.
Chuck Humphrey, Kathleen Shearer, Martha Whitehead   +2 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Toward a Humanist and Agentic Paradigm of Inclusive Teaching—Lessons from the United States Civil Rights Era for College Pedagogy

Teaching & Learning Inquiry: The ISSOTL Journal
Inclusive teaching is a potentially transformative mindset and approach to reimagining education. To realize its full potential, we must be willing to redefine what it means to teach.
Bryan M. Dewsbury
doaj   +1 more source

Qualitative process evaluation of the Perioperative Quality Improvement Programme (PQIP): study protocol

BMJ Open, 2019
Introduction The Perioperative Quality Improvement Programme (PQIP) is designed to measure complications after major elective surgery and improve these through feedback of data to clinicians.
Naomi J Fulop, Cecilia Vindrola-Padros, Duncan Wagstaff, S Ramani Moonesinghe   +3 more
doaj   +1 more source

Spontaneous Scaling of a Primary Care Innovation in Real-Life Conditions: Protocol for a Case Study

JMIR Research Protocols, 2023
BackgroundScaling effective primary care innovations to benefit more people is of interest to decision makers. However, we know little about how promising innovations are being scaled “spontaneously,” that is, without deliberate ...
France Légaré, Diogo G V Mochcovitch, Roberta de Carvalho Corôa, Amédé Gogovor, Ali Ben Charif, Cynthia Cameron, Annie Plamondon, Marie Cimon, Sabrina Guay-Bélanger, Geneviève Roch, Maxine Dumas Pilon, Jean-Sébastien Paquette, Robert K D McLean, Andrew Milat   +13 more
doaj   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source