Results 71 to 80 of about 114,951 (282)
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Report of the Second Meeting of the Coordination Committee [PDF]
, 2004 The Second meeting of the Coordination Committee of the MedSudMed Project (Assessment and monitoring of the fishery resources and the ecosystems in the Straits of Sicily) was attended by representatives of participating countries (Tunisia, Malta, Libya,
Alessi, A.L.
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Report of the 7th Ad-hoc Meeting of the Project Steering Committee
, 2022 This report is under the SEAFDEC/UNEP/GEF Project on “Establishment and Operation of a Regional System of Fisheries Refugia in the South China Sea and Gulf of Thailand”The SEAFDEC/Project Coordination Unit (PCU) organized the 7th Ad-hoc Meeting of the ...
SEAFDEC
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Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone +8 more
wiley +1 more source
The clinical trial activation process: a case study of an Italian public hospital
TrialsBackground/aims In order to make the centers more attractive to trial sponsors, in recent years, some research institutions around the world have pursued projects to reorganize the pathway of trial activation, developing new organizational models to ...
Carolina Pelazza +4 more
doaj +1 more source
Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig +9 more
wiley +1 more source
How should donors give foreign aid? Project aid versus budget support [PDF]
We develop a theoretical model to compare the two major foreign aid modalities: project aid and budget support. These two modalities have a different impact on the production of 'developmental goods'. Firstly, conditionality can be associated with budget
Izabela Jelovac, Frieda Vandeninden
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Partnering for the greater good: the role of the private sector in promoting economic growth and reducing poverty in the Indo-Pacific region [PDF]
, 2015 In 2014, the Minister for Foreign Affairs launched a new development policy that changed the way Australian aid is to be delivered. Increasing engagement with our private sector, both in Australia and in developing countries, promoting gender equity and ...
Sharman Stone
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Coordination in temporary organizations
, 2018 Purpose The purpose of this paper is to explore intra-firm coordination in temporary organizations (TOs). Specifically, it identifies and explains how operational coordination evolves over time in a particular TO: the 2016 Olympic Games Organizing ...
Martin Spring +2 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source