Results 41 to 50 of about 37,320 (265)

The effect of governance and governmentality on project portfolio success

Acta Commercii
Orientation: Although project portfolio is a renowned tradition in organisations, its effective management remains a challenge. Research purpose: The aim of the study was to investigate the effect of governance and governmentality on project portfolio ...
Joseph S. Mohosho, Kwete Mwana Nyandongo, Shopee Dube   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Development of a data-driven urban immunity assessment model: providing a new benchmark for urban governance under public health emergencies

Frontiers in Public Health
Public health emergencies (PHEs) pose significant challenges to global urban governance systems, necessitating the establishment of more efficient and dynamically adaptive response mechanisms.
Peng Cui, Peng Cui, Saiya Cao, Ruize Qin, Fan Zhang   +4 more
doaj   +1 more source

Institutionalising informal networks of the urban poor under an enabling paradigm: a case study on Greenland slum of Khulna city in Bangladesh

International Journal of Urban Sustainable Development, 2020
This paper addresses the persistent challenges in housing the urban poor in Bangladesh. In particular, it explores the empirical evidence on informal networks of the urban poor as they relate to service provision in low-income settlements of Khulna City.
Md. Ashiq Ur Rahman, Astrid Ley
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The Governance of PPP Project Resilience: A Hybrid DMATEL-ISM Approach

Systems
Considering the inherent characteristics of long-term agreements, public–private partnership (PPP) projects are confronted with diverse uncertainties and external challenges.
Zhankun Liu, Nannan Wang, Qiushi Du
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Caminhos de enfrentamento das arboviroses na Paraíba: a governança na 6ª Gerência Regional de Saúde

Revista Principia, 2019
Brazilian society has been facing, since the year of 2015, a large outbreak of so-called arboviruses caused by Aedes aegypti. Since then, numerous studies have sought alternatives for actions in the areas of public health, education and other social ...
Ayalla Cândido Freire, Felipe César Silva Brito, Adriele Mercia Souza de Assis, Mayara Santiago Monteiro, Francisca Mikaely Pacheco da Silva   +4 more
doaj   +1 more source