Results 51 to 60 of about 37,320 (265)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

COMMUNICATION STRATEGIES AND MECHANISMS OF PUBLIC MANAGEMENT OF COAL COMMUNITIES IN THE CONDITIONS OF MODERN CHALLENGES

Baltic Journal of Economic Studies
The article is devoted to the study of communication strategies and mechanisms of public governance of coal communities in the face of modern challenges through the analysis of new approaches to public administration. The subject of the present study is
Liubov Kvasnii, Svyatoslav Kostyuk, Nataliia Voitovych   +2 more
doaj   +1 more source

Governance mechanisms and practices in project-based interorganisational collaboration for innovation

International Journal of Project Management
This study explores how project-based interorganisational collaboration for innovation employs formal contracts and relational governance in governance practices to fulfil different governance needs. The study sheds light on the previously unexplored interplay among the formal contracts, relational agreements and governance practices of project-based ...
Katri Valkokari, Jaakko Paasi, Soili Nysten-Haarala, Jouko Nuottila, Anna Hurmerinta-Haanpää   +4 more
openaire   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Governance, contracts, and culture: A triadic approach to megaproject performance

Project Leadership and Society
Despite their transformative ambitions, transport megaprojects, such as high-speed rail systems, often underperform. This study investigates the California High-Speed Rail Project (CAHSRP) using a critical realist methodology and a Context-Mechanism ...
Jackson Sekasi, Steven Harrod, Victor Andrade   +2 more
doaj   +1 more source

Environmental Diplomacy in the Context of Global Environmental Governance: A Case Study of the Sumatra Merang Peatland Project [PDF]

E3S Web of Conferences
International cooperation in ecosystem management and restoration is a crucial strategy for mitigating global climate change. This study analyzes the dynamics of international cooperation in the Sumatra Merang Peatland Project (SMPP), a peatland ...
Akbar Dhanang Fawaiz, Fatmawati Fatmawati, Siahaan Munawir, Nurmalia Denisa   +3 more
doaj   +1 more source

Hard and soft governance mechanisms for large projects. A historical perspective

Journal of Management History
Purpose Drawing motivation from the greater exposure to uncertainty and condition changes that affect large projects due to their long lifecycle, this paper aims to investigate how the time factor affects the use of governance mechanisms to pursue the success of these projects.
GIORGINO MARIA CLEOFE, BARNABE' FEDERICO
openaire   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Assessing the role of territorial governance in the success of territory projects: A case study of the Fez craft industry

Moroccan Journal of Quantitative and Qualitative Research
Territorial governance has become omnipresent in all economic, political or social discourses, it is a question of implementing dynamic processes of coordination, pooling efforts, shared visions of different actors of a territory and diverse resources ...
saarra boutahar, Bouchra Debbagh
doaj   +1 more source