Results 61 to 70 of about 37,320 (265)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Risk Management and Governance in Blockchain-Based Digital Identity Projects: A Business Analysis and Project Management Framework

ITEGAM-JETIA
Blockchain is viewed as a revolutionary solution to digital identity management, offering decentralization, security, and user control over one’s own private identity.
Tobiloba Kazeem, Olatoye Kabiru Agboola, Nonso Okika, Soyingbe Folasade Owoola-Adebayo, Fope Opeola, Nnenna Linda Akunna, Oreoluwa Serifat Abimbola   +6 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

The Impact of Contractual Governance on Project Performance in Urban Sewage Treatment Public–Private Partnership Projects: The Moderating Role of Administrative Efficiency

Buildings
In public–private partnership (PPP) projects, the private sector’s performance is influenced by administrative efficiency, and the impact varies across different contractual dimensions.
Jialin Gui, Jinbo Song, Wen Xia
doaj   +1 more source

Women, Water Resource Management, and Sustainable Development: The Turkey-North Cyprus Water Pipeline Project

Resources, 2018
Women’s role in water resource management is recognized, yet the implementation of methods and strategies to get beyond gender-based obstacles to women’s equal participation in water resource management related projects remain vague ...
Emine Eminel Sülün
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Governance challenges to realising the potential of ecosystem-based adaptation in Bangladesh

Ecosystems and People
Wetlands are under stress due to the impacts of climate change and ecological degradation. This warrants the need for an effective governance that ensures sustainability of these critical ecosystems and supports community resilience.
Syed Mohammad Aminur Rahman, Melissa Nursey-Bray, Md. Masud-All-Kamal   +2 more
doaj   +1 more source

Spatio-temporal Full-cycle Integrated Framework for Old Residential Community Renovation: Theoretical Construction, Mechanism Analysis, and Case Study [PDF]

E3S Web of Conferences
The renovation of old residential quarters often faces challenges such as lack of spatio-temporal coordination and fragmented governance. Integrating theories of whole-cycle management, spatial production, and sustainable development, this study develops
Han Liying, Zhang Ying, Li Juan
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Factors influencing sustainability performance in public-private partnerships for transportation in China

Discover Sustainability
Achieving the sustainability goals of transportation Public-Private Partnership (PPP) projects in China remains a pressing challenge. Project governance mechanisms play a crucial role in advancing the sustainable development of such projects.
Shuangyu Yang, Supit Boonlab, Wanjai Lamprom   +2 more
doaj   +1 more source