Results 31 to 40 of about 198,428 (256)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Criticality of Schedule Constraints – Classification and Identification for Project Management [PDF]

Journal of Engineering, Project, and Production Management, 2014
In construction scheduling, constraints among activities are vital as they govern the schedule solution. Understanding their criticality is essential for better schedule management.
Qui T. Nguyen, David K. H. Chua
doaj  

Reactive project scheduling method to enhance project progress under uncertainty

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2016
This study proposes a new method for reactive project scheduling that enhances a smooth progress of a project, which is referred to as a “degree of project progress (DPP).” The proposed method generates a so called revision plan for the rest of a current
Haruhiko SUWA, Daisuke MORITA
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Multi-Factor superposition influence analysis in engineering projects: a Bayesian network approach

Journal of Asian Architecture and Building Engineering
The existing studies rarely examine whether multiple risk factors superimposed on a particular activity result in superposed or non-superposed effects.
Chaoyong Zhang, Keming Hu, Xun Liu
doaj   +1 more source

Multi-objective optimization design of steel structure building energy consumption simulation based on genetic algorithm

Nonlinear Engineering, 2022
In order to solve the problems of data acquisition, quantitative analysis and model solving in the field of construction schedule optimization, a construction schedule optimization system based on genetic algorithm was constructed.
Ren Yuan, Rubaiee Saeed, Ahmed Anas, Othman Asem Majed, Arora Sandeep Kumar   +4 more
doaj   +1 more source

Linking partnering success factors to project performance - Findings from two nation-wide surveys

Project Leadership and Society, 2021
In this article we present findings from an investigation into the influence of partnering success factors on multi-partner projects’ abilities to meet time schedule, budget, and technical specifications.
Kristina Nevstad, Tage Koed Madsen, Pernille Eskerod, Wenche Kristin Aarseth, Anniken Susanne T. Karlsen, Bjørn Andersen   +5 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Developing computer-based schedule delay analysis methods based on information flow analysis: a case study

Journal of Civil Engineering and Management, 2013
Schedule analysts often resolve diverse schedule delay problems in construction projects based on their subjective experiences. Although various process-based and mathematical-model schedule delay analysis methods are available for effective schedule ...
Ming-Kuan Tsai, Jyh-Bin Yang, Nie-Jia Yau   +2 more
doaj   +1 more source