Results 91 to 100 of about 2,172,362 (285)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Global, regional, and national burden of laryngeal cancer attributable to smoking, 1990–2021, and projections to 2036: a systematic analysis of the Global Burden of Disease study 2021

Frontiers in Public Health
BackgroundLaryngeal cancer, predominantly linked to smoking, persists as a formidable global health challenge. Acquiring a deeper understanding of laryngeal cancer attributable to smoking (LCAS) burden and trends is essential for crafting nuanced and ...
Liangwen Shi, Zhixing Kuang, Jiannan Tu, Taiqin Wang, Tao Liu, Jingbo Liu, Jianzhi Liu   +6 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Projected Changes in Maternal Heat Exposure During Early Pregnancy and the Associated Congenital Heart Defect Burden in the United States

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background More intense and longer‐lasting heat events are expected in the United States as a consequence of climate change. This study aimed to project the potential changes in maternal heat exposure during early pregnancy (3–8 weeks post conception ...
Wangjian Zhang, Tanya L. Spero, Christopher G. Nolte, Valerie C. Garcia, Ziqiang Lin, Paul A. Romitti, Gary M. Shaw, Scott C. Sheridan, Marcia L. Feldkamp, Alison Woomert, Syni‐An Hwang, Sarah C. Fisher, Marilyn L. Browne, Yuantao Hao, Shao Lin   +14 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Burden of drug use disorders from 1990 to 2021 and projection to 2050 in China: findings from the 2021 global burden of disease study

Frontiers in Pharmacology
BackgroundDrug use disorders (DUDs) represent a major public health challenge globally, including China. This study investigated the impact of DUDs in China over the past 3 decades and examined the long-term trends in their epidemiological ...
Shuzheng Yu, Yanting Chen, Shaohua Huang, Bing Wang, Qingrong Wu   +4 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Projected Emergence Seasons of Year‐Maximum Near‐Surface Wind Speed

Geophysical Research Letters
Global warming is expected to have far‐reaching impacts on the frequency and intensity of extreme events, but the effects of anthropogenic warming on the emergence seasons of year‐maximum near‐surface wind speed (NSWS) remain poorly understood.
Yue Yu, Zhibo Li, Zixiang Yan, Huishuang Yuan, Cheng Shen   +4 more
doaj   +1 more source

Classes of homothetic convex sets

Extracta Mathematicae
This is a survey of known results and still open problems on characteristic properties of classes of homothetic convex sets in the n-dimensional Euclidean space.
Valeriu Soltan
doaj   +1 more source