Results 81 to 90 of about 899,437 (254)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
, 2021 Pre-release for the RSC Open article: Projection to Latent Correlative Structures, a Dimension Reduction Strategy for Spectral-Based ...
Guillaume Erny
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Frontiers in PharmacologyBackgroundDrug use disorders (DUDs) represent a major public health challenge globally, including China. This study investigated the impact of DUDs in China over the past 3 decades and examined the long-term trends in their epidemiological ...
Shuzheng Yu +4 more
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
When Choreography Marries Digital Projection [PDF]
, 2016 As a choreographer, I have always had a keen interest in fusing movement with other art forms and in being able to achieve this seamlessly. Each art form is as important as another; therefore making this a reality can be challenging.
Marshall, A.
core +1 more source
Classes of homothetic convex sets
Extracta MathematicaeThis is a survey of known results and still open problems on characteristic properties of classes of homothetic convex sets in the n-dimensional Euclidean space.
Valeriu Soltan
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Viscoelastic spatial light modulators and schlieren-optical systems for HDTV projection displays
, 2022 S.69-78Thin metallized viscoelastic layers coated by a mirror electrode and addressed by an active matrix are proposed for use in schlieren-optical light-valve projection systems for high-definition television (HDTV).
Brinker, W. +6 more
core +1 more source