Results 81 to 90 of about 2,172,362 (285)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Frontiers in EndocrinologyBackgroundPancreatic cancer (PC) is a prevalent malignancy within the digestive system, with diabetes recognized as one of its well-established risk factors.MethodsData on PC mortality attributed to high fasting blood sugar were retrieved from the Global
Yongguang Wei +27 more
doaj +1 more source
Environmental Research Letters, 2019 Dysentery, an acute infectious disease still prevalent in many parts of the world, especially in developing counties, is caused by a group of bacteria known as Shigella . Because of the sensitivity of dysentery to climate change, the relationship between
Chenlu Li +5 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Health Expenditure Scenarios in the New Member States: Country Report on Poland. ENEPRI Research Reports No. 47, 19 December 2007 [PDF]
, 2007 The objective of this report is to present the model of future health care system revenues and expenditures in Poland, and to discuss assumptions for the projection and projection results. Expenditure analysis is based on ILO social budget model, part of
Golinowska, Stanislawa +2 more
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Los embriones congelados frente al derecho sucesorio
Vergentis. Revista de Investigación de la Cátedra Internacional Conjunta Inocencio III, 2020 The question arises as to whether cryopreserved embryos are or can be heirs. Its situation incites more and more uncertainty and generates more conflicts of a juridical nature: filiatorial, inbreeding, identity, registration, succession, still unresolved.
Susana Isabel Estrada
doaj
Risk Management and Healthcare Policy, 2023 Alla Alsharif,1,* Maha T Alsharif,2,* Meyassara Samman,3,* Nada Binmadi,2,* Saba Kassim,1,* Samah Mourad,4,* Saman Warnakulasuriya5,6,* 1Department of Preventive Dental Sciences, Taibah University Dental College & Hospital, Al-
Alsharif A +6 more
doaj
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source