Results 41 to 50 of about 615,778 (249)

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Alar cartilage flap for projection of the nasal tip [PDF]

Revista Brasileira de Cirurgia Plástica, 2018
Introduction: The nasal tip is a frequent object of study by surgeons, since it is a common reason for pre- and postoperative complaints. Thus, the tip should be thoroughly evaluated to determine the best technique to be used.
José Carlos Daher, Milena Carvalho Almeida Galdino, Luciano Gomes Moura, Leonardo Martins Costa Daher, Ismar Ribeiro, Gabriel Campelo dos Santos, Leonardo David Pires Barcelos, Cesar Augusto Daher Ceva Faria   +7 more
doaj   +1 more source

Images Avant la Lettre. The Mystery of Ink Blots in Psychology, Design and Art

img journal, 2023
The paper starts out with a figure of speech –avant la lettre– and points, through a review of literature, to a variety of disciplinary explanations regarding processes before language was ever spoken.
Michael Renner
doaj   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Prediction and validation of potential transmission risk of Dirofilaria spp. infection in Serbia and its projection to 2080

Frontiers in Veterinary Science
Animal and human dirofilariosis is a vector-borne zoonotic disease, being one of the most important diseases in Europe. In Serbia, there are extensive studies reporting the presence of Dirofilaria immitis and D. repens, mainly in the north of the country,
Iván Rodríguez-Escolar, Ricardo Enrique Hernández-Lambraño, Ricardo Enrique Hernández-Lambraño, José Ángel Sánchez-Agudo, José Ángel Sánchez-Agudo, Manuel Collado-Cuadrado, Sara Savić, Marina Žekić Stosic, Doroteja Marcic, Rodrigo Morchón, Rodrigo Morchón   +10 more
doaj   +1 more source

Projected Changes in Maternal Heat Exposure During Early Pregnancy and the Associated Congenital Heart Defect Burden in the United States

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background More intense and longer‐lasting heat events are expected in the United States as a consequence of climate change. This study aimed to project the potential changes in maternal heat exposure during early pregnancy (3–8 weeks post conception ...
Wangjian Zhang, Tanya L. Spero, Christopher G. Nolte, Valerie C. Garcia, Ziqiang Lin, Paul A. Romitti, Gary M. Shaw, Scott C. Sheridan, Marcia L. Feldkamp, Alison Woomert, Syni‐An Hwang, Sarah C. Fisher, Marilyn L. Browne, Yuantao Hao, Shao Lin   +14 more
doaj   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

The Plural/Singular in Pierre Huyghe’s Interventions in the 1990s

Open Cultural Studies, 2022
The essay aims to reexamine the underlying contexts and the nature of site-specific projection in Light Conical Intersect by Pierre Huyghe by addressing the critical intervention of Gordon Matta-Clark in public space. The essay offers a broad overview of
Lipiński Kamil
doaj   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source