Results 81 to 90 of about 2,155,686 (262)

Climate change impacts the epidemic of dysentery: determining climate risk window, modeling and projection

Environmental Research Letters, 2019
Dysentery, an acute infectious disease still prevalent in many parts of the world, especially in developing counties, is caused by a group of bacteria known as Shigella . Because of the sensitivity of dysentery to climate change, the relationship between
Chenlu Li, Xiaoxu Wu, Duoying Ji, Jianing Liu, Jie Yin, Zhiyi Guo   +5 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Los embriones congelados frente al derecho sucesorio

Vergentis. Revista de Investigación de la Cátedra Internacional Conjunta Inocencio III, 2020
The question arises as to whether cryopreserved embryos are or can be heirs. Its situation incites more and more uncertainty and generates more conflicts of a juridical nature: filiatorial, inbreeding, identity, registration, succession, still unresolved.
Susana Isabel Estrada
doaj  

Forecasting Head and Neck Cancer Trends in GCC Countries: Implications for Public Health Policy and Strategy

Risk Management and Healthcare Policy, 2023
Alla Alsharif,1,* Maha T Alsharif,2,* Meyassara Samman,3,* Nada Binmadi,2,* Saba Kassim,1,* Samah Mourad,4,* Saman Warnakulasuriya5,6,* 1Department of Preventive Dental Sciences, Taibah University Dental College & Hospital, Al-
Alsharif A, Alsharif MT, Samman M, Binmadi N, Kassim S, Mourad S, Warnakulasuriya S   +6 more
doaj  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Global, regional, and national burden of laryngeal cancer attributable to smoking, 1990–2021, and projections to 2036: a systematic analysis of the Global Burden of Disease study 2021

Frontiers in Public Health
BackgroundLaryngeal cancer, predominantly linked to smoking, persists as a formidable global health challenge. Acquiring a deeper understanding of laryngeal cancer attributable to smoking (LCAS) burden and trends is essential for crafting nuanced and ...
Liangwen Shi, Zhixing Kuang, Jiannan Tu, Taiqin Wang, Tao Liu, Jingbo Liu, Jianzhi Liu   +6 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Projected Changes in Maternal Heat Exposure During Early Pregnancy and the Associated Congenital Heart Defect Burden in the United States

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background More intense and longer‐lasting heat events are expected in the United States as a consequence of climate change. This study aimed to project the potential changes in maternal heat exposure during early pregnancy (3–8 weeks post conception ...
Wangjian Zhang, Tanya L. Spero, Christopher G. Nolte, Valerie C. Garcia, Ziqiang Lin, Paul A. Romitti, Gary M. Shaw, Scott C. Sheridan, Marcia L. Feldkamp, Alison Woomert, Syni‐An Hwang, Sarah C. Fisher, Marilyn L. Browne, Yuantao Hao, Shao Lin   +14 more
doaj   +1 more source