Results 81 to 90 of about 2,282,257 (312)

“Here, I am More than Just Symptoms Combined”: Mental Health Services from the Perspective of Community Rehabilitation Groups

Journal of Patient Experience
In response to the rise in mental disorders, psychosocial and community approaches have been proposed, complementing traditional clinical services.
Felipe Agudelo Hernández PhD, MD, Daniela Rojas Loaiza MD, Eduardo Marulanda MD   +2 more
doaj   +1 more source

Health Expenditure Scenarios in the New Member States: Country Report on Poland. ENEPRI Research Reports No. 47, 19 December 2007 [PDF]

, 2007
The objective of this report is to present the model of future health care system revenues and expenditures in Poland, and to discuss assumptions for the projection and projection results. Expenditure analysis is based on ILO social budget model, part of
Golinowska, Stanislawa, Kocot, Ewa, Sowa, Agnieszka.   +2 more
core  

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Pancreatic cancer mortality trends attributable to high fasting blood sugar over the period 1990–2019 and projections up to 2040

Frontiers in Endocrinology
BackgroundPancreatic cancer (PC) is a prevalent malignancy within the digestive system, with diabetes recognized as one of its well-established risk factors.MethodsData on PC mortality attributed to high fasting blood sugar were retrieved from the Global
Yongguang Wei, Yongguang Wei, Yongguang Wei, Zedong Qin, Xiwen Liao, Xiwen Liao, Xiwen Liao, Xin Zhou, Xin Zhou, Xin Zhou, Huasheng Huang, Huasheng Huang, Huasheng Huang, Chenlu Lan, Chenlu Lan, Chenlu Lan, Wei Qin, Wei Qin, Wei Qin, Guangzhi Zhu, Guangzhi Zhu, Guangzhi Zhu, Hao Su, Hao Su, Hao Su, Tao Peng, Tao Peng, Tao Peng   +27 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Los embriones congelados frente al derecho sucesorio

Vergentis. Revista de Investigación de la Cátedra Internacional Conjunta Inocencio III, 2020
The question arises as to whether cryopreserved embryos are or can be heirs. Its situation incites more and more uncertainty and generates more conflicts of a juridical nature: filiatorial, inbreeding, identity, registration, succession, still unresolved.
Susana Isabel Estrada
doaj  

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source