Results 41 to 50 of about 365,712 (267)

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk   +10 more
wiley   +1 more source

Projection in Interaction and Projection in Grammar [PDF]

open access: yesText - Interdisciplinary Journal for the Study of Discourse, 2005
AbstractIn this paper, I argue that there are fundamental common features shared by interaction and grammar that suggest some kind of interdependence between the two and a nonautonomy of the language faculty; one of these fundamental common features is that of ‘projectability’.
openaire   +3 more sources

Comparative Analysis of Posiphen Pharmacokinetics across Different Species—Similar Absorption and Metabolism in Mouse, Rat, Dog and Human

open access: yesBiomolecules
Posiphen is a small molecule that exhibits neuroprotective properties by targeting multiple neurotoxic proteins involved in axonal transport, synaptic transmission, neuroinflammation, and cell death.
Maria L. Maccecchini, Diane R. Mould
doaj   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin   +17 more
wiley   +1 more source

Assessing the impact of bias correction approaches on climate extremes and the climate change signal

open access: yesMeteorological Applications
We assess the impact of three bias correction approaches on present day means and extremes, and climate change signal, for six climate variables (precipitation, minimum and maximum temperature, radiation, vapour pressure and mean sea level pressure) from
Hong Zhang   +4 more
doaj   +1 more source

Regional and elevational patterns of extreme heat stress change in the US

open access: yesEnvironmental Research Letters, 2022
Increasing severity of extreme heat is a hallmark of climate change. Its impacts depend on temperature but also on moisture and solar radiation, each with distinct spatial patterns and vertical profiles. Here, we consider these variables’ combined effect
Colin Raymond   +8 more
doaj   +1 more source

The Impact of the COVID‐19 Pandemic on Childhood Cancer Survival: A Population‐Based Assessment of Survival Patterns Between 2015 and 2023 in Germany

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann   +8 more
wiley   +1 more source

The chemfp Project [PDF]

open access: yesJournal of Cheminformatics, 2019
This paper describes the 10 years of work and research results of the chemfp project, available from http://chemfp.com/ . The project started as a way to promote the FPS format for cheminformatics fingerprint exchange. This is a line-oriented text format meant to be easy to read and write.
openaire   +3 more sources

Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari   +5 more
wiley   +1 more source

Substantial increases in future precipitation extremes—insights from a large ensemble of downscaled CMIP6 models

open access: yesnpj Natural Hazards
We investigated projected changes to daily mean, common extreme (99th and 99.7th percentile), and rare extreme (annual exceedance probability (AEP) 1 in 10, 50, and 100) precipitation events across Australia and its greater capital cities using a large ...
Rohan Eccles   +8 more
doaj   +1 more source

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