Results 51 to 60 of about 1,787 (266)

Equivalence Relations Between Conical 2-Designs and Mutually Unbiased Generalized Equiangular Tight Frames

open access: yesMathematics
Quantum measurements play a fundamental role in quantum information. Therefore, increasing efforts are being made to construct symmetric measurement operators for qudit systems.
Katarzyna Siudzińska
doaj   +1 more source

Some New Components of the Moduli Scheme MP3(2; -1; 2; 0) of Stable Coherent Torsion Free Sheaves of Rank 2 on P3

open access: yesМоделирование и анализ информационных систем, 2015
In this paper we consider Giseker-Maruyama moduli scheme M := MP3(2;¡1; 2; 0) of stable coherent torsion free sheaves of rank 2 with Chern classes c1 = -1, c2 = 2, c3 = 0 on 3-dimensional projective space P3.
M. A. Zavodchikov
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

On some interpretation of linear frames in projective differential geometry

open access: yesДифференциальная геометрия многообразий фигур, 2018
The centroprojective group, i. e. the stabilizer G of a fixed point A in the group GP(n) of projective transformations of n-dimensional projective space Pn (n > 1) is considered in the paper. Two faithful representations of the linear quotient group of G
A. Kuleshov
doaj  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Enochs conjecture for cotorsion pairs over recollements of exact categories

open access: yesOpen Mathematics
Let (A,C,ℬ)\left({\mathcal{A}},{\mathcal{C}},{\mathcal{ {\mathcal B} }}) be a recollement of exact categories. An explicit procedure about gluing complete hereditary cotorsion pairs from A{\mathcal{A}} and ℬ{\mathcal{ {\mathcal B} }} to C{\mathcal{C ...
Hu Jiangsheng   +3 more
doaj   +1 more source

Stable Sheave Moduli of Rank 2 with Chern Classes c 1 = -1; c2 = 2; c3 = 0 on Q3

open access: yesМоделирование и анализ информационных систем, 2015
In this paper we consider the scheme MQ( 2;¡1; 2; 0 ) of stable torsion free sheaves of rank 2 with Chern classes c1 = -1, c2 = 2, c3 = 0 on a smooth 3-dimensional projective quadric Q.
A. D. Uvarov
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

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