Results 81 to 90 of about 1,787 (266)
Heterotic instanton superpotentials from complete intersection Calabi-Yau manifolds
Journal of High Energy Physics, 2017 We study Pfaffians that appear in non-perturbative superpotential terms arising from worldsheet instantons in heterotic theories. A result by Beasley and Witten shows that these instanton contributions cancel among curves within a given homology class ...
Evgeny Buchbinder +3 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
The Comparative Project on Class Structure and Class Consciousness
IASSIST Quarterly, 1989 The Comparative Project on Class Structure and Class ...
openaire +2 more sources
Starter Projects in Python Programming Classes
, 2022 Starter projects are part of constructionist learning arrangements (1, 2). The term was mainly coined by the Scratch community and describes a simple, executable program that is designed to encourage copying, exploring and further development. This contribution first discusses three types: test programs, examples that illustrate programming techniques ...
openaire +2 more sources
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
On a generalization of I-regularity
Open MathematicsLet SS be a pomonoid. The projectivity and strong flatness of right SS-posets have been central topics in the homological classification of pomonoids in recent decades. In 2005, Shi et al. introduced II-regular SS-posets and proved that all its cyclic SS-
Qiao Husheng, Feng Leting
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source