Results 81 to 90 of about 190,046 (323)

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

Monads on projective spaces [PDF]

open access: yesCommunications in Algebra, 2000
This is a little investigation into the classification of complexes of direct sums of line bundles on projective spaces. We consider complexes on projective k-space Pk : O_Pk(-1)^a --> O_Pk^b --> O_Pk(1)^c, with the first map injective and the second map surjective. This is called a monad.
openaire   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Strongly not relatives Kähler manifolds

open access: yesComplex Manifolds, 2017
In this paper we study Kähler manifolds that are strongly not relative to any projective Kähler manifold, i.e. those Kähler manifolds that do not share a Kähler submanifold with any projective Kähler manifold even when their metric is rescaled by the ...
Zedda Michela
doaj   +1 more source

Metrizations of Projective Spaces [PDF]

open access: yesProceedings of the American Mathematical Society, 1957
A two-dimensional G-space,1 in which the geodesic through two distinct points is unique, is either homeomorphic to the plane E2 and all geodesics are isometric to a straight line, or it is homeomorphic to the projective plane p2 and all geodesics are isometric to the same circle, see [1, ??10 and 31]. Two problems arise in either case: (1) To determine
openaire   +1 more source

Projective bitopological spaces II. [PDF]

open access: yesJournal of the Australian Mathematical Society, 1972
Gleason [3] proved that in the category G of compact Hausdorff spaces and continuous maps, the projective objects are precisely the extremally disconnected spaces contained in the category. Strauss [7] generalised this and proved that in the category G of regular Hausdorif spaces and perfect maps the projective objects are again precisely the ...
openaire   +2 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

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