Results 81 to 90 of about 10,221 (208)

Consensus Guideline for the Diagnosis and Treatment of Tyrosine Hydroxylase (TH) Deficiency

Journal of Inherited Metabolic Disease, Volume 48, Issue 6, November 2025.
ABSTRACT Tyrosine hydroxylase (TH) catalyses the rate‐limiting step in dopamine biosynthesis. Autosomal recessive tyrosine hydroxylase deficiency (THD) leads to clinical phenotypes reflecting the deficiency of dopamine, norepinephrine, or epinephrine in the central nervous system (CNS), presenting along a continuous spectrum from mild to severe forms ...
Mariya Sigatullina Bondarenko, Oya Kuseyri Hübschmann, Jan Kulhánek, Roser Pons, Toni S. Pearson, Kathrin Jeltsch, Ivana Badnjarevic, Tessa Wassenberg, Gabriella Horvath, Galina Stevanovic, Manju A. Kurian, Elisenda Cortès‐Saladelafont, Agathe Roubertie, Vincenzo Leuzzi, Mariarita Bertoldi, Mario Mastrangelo, Birgit Assmann, THD Guidelines Working Group, Ines Denzler, Clarisa Maxit, Natalia Alexandra Julia‐Palacios, Shekeeb Mohammad, Helly Goez, Wai‐Ian Yeung, Tomáš Honzík, Ivana Kavecan, Alba Tristán‐Noguero, Alberto Burlina, Daniela Gueraldi, Sushil Bandodkar, Willemsen Michel, Francesco Porta, Sheila Wong, Filippo Manti, Reem Alkhater, Chris Mühlhausen, Alice Kuster, Dimitrios Zafeiriou, Paulo Sgobbi, Wladimir Bocca Vieira de Rezende Pinto, Angeles Garcia‐Cazorla, Thomas Opladen   +41 more
wiley   +1 more source

Etiology, functional status and short term outcome of patients with pituitary lesions. An experience from a developing country [PDF]

, 2009
OBJECTIVE: To describe the etiology, functional status and short term outcome of patients with pituitary lesions (PL). METHODS: Brain or pituitary MRI reports of 3753 patients were analyzed for PL over the period of 2000 to 2007, done at the Aga Khan ...
Haq, Mansoor Ul, Ishtiaq, Osama, Jabbar, Abdul, Masood, Mohammad Qamar, Mehar, Saeed, Rizwan, Azra   +5 more
core   +1 more source

Giant prolactinoma with progressive cranial settling and central herniation: a case report

Journal of Medical Case Reports
Background Giant prolactinoma (size > 4 cm) is a rare condition and accounts for less than 1% of pituitary adenomas. In even rarer cases, these lesions may involve craniocervical structures requiring surgical intervention. The present case is the largest
Taha Shahbazi, Soheil Abdollahi Yeganeh, Shiva Borzouei, Mahdi Arjipour   +3 more
doaj   +1 more source

Premature pubarche as a first presentation of pituitary macroprolactinoma

Journal of Research in Medical Sciences, 2020
Prolactinoma is a rare tumor of childhood. Clinical presentations of prolactinoma include amenorrhea, delayed puberty, and galactorrhea. For the first time, in this case, elevated prolactin levels were associated with unexpected premature pubarche.
Fatemeh Tabatabaei, Mohammad Reza Sharif, Hossein Nasr Esfahani, Razieh Yazdi Zahrani, Abolfazl Taheri, Rokhsareh Meamar   +5 more
doaj   +1 more source

Prenatal alcohol exposure increases the aggressiveness of estrogen‐induced pituitary tumors in male rats

Alcohol, Clinical and Experimental Research, Volume 49, Issue 11, Page 2461-2469, November 2025.
Prenatal alcohol exposure (PAE) enhances the development of aggressive pituitary tumors (PitNETs) in female rats. In this study, we found that PAE also promotes the development of PitNETs in male rats. Like in females, PAE treatment enhances the expression of stem cell and tumor aggressiveness genes and increases tumor cell proliferation rate ...
Shaista Chaudhary, Dipak K. Sarkar
wiley   +1 more source

Medical treatment of prolactinomas. [PDF]

, 2011
Prolactinomas, the most prevalent type of neuroendocrine disease, account for approximately 40% of all pituitary adenomas. The most important clinical problems associated with prolactinomas are hypogonadism, infertility and hyposexuality.
A Barlier, A Beckers, A Chattopadhyay, A Ciccarelli, A Colao, A Colao, A Colao, A Colao, A Colao, A Colao, A Colao, A Colao, A Colao, A Colao, A Colao, A Colao, A Colao, A Colao, A Colao, A Colao, A Colao, A Di Sarno, A Di Sarno, A Klibanski, A Liuzzi, A Saveanu, A Wakil, A Zárate, AG Lania, AI McCormack, AM Colao, Annamaria Colao, AP Heaney, BM Biller, C Di Somma, C Ferrari, C Rasmussen, C Wang, CY Choong, D Cheung, D Dallabonzana, D McCall, DA De Luis, DA Sisam, DG Johnston, DG Johnston, E Delgrange, E Delgrange, E Delgrange, E Valassi, EJ Lee, F Andersohn, F Bogazzi, F Bogazzi, FF Casanueva, G Raverot, G Schettini, G Zada, GA Kaltsas, HE Turner, I Shimon, I Shimon, J Gorski, J Kharlip, J Schlechte, J Verhelst, J Webster, JC Williams, JJ Orrego, JK Devin, JM Wilson, JP Singh, JS Bevan, JW van't Verlaat, K Thapar, K Thapar, KJ Gräf, L Vilar, LB Nachtigall, LC Tan, LD George, LJ Hofland, M Biswas, M De Rosa, M De Rosa, M De Rosa, M Esteller, M Giusti, M Kars, M Kars, M Lafeber, M Muratori, M Ono, M Rocheville, M Steiger, MC Koppelman, MD Bronstein, ME Molitch, ML Vance, MP Gillam, MP Gillam, MS Huda, N Herring, OM Dekkers, P Fainstein Day, P Lancellotti, P Moriondo, PG Crosignani, PU Freda, R Homburg, R Schade, R Zanettini, RB Rothman, S Cannavò, S Ekeblad, S Karunakaran, S Mohammed, S Vallette, SG Ren, Silvia Savastano, SW Lamberts, SW Lamberts, T Mindermann, T Sabuncu, T Tan, V Goffin, VG Rasmussen, VQ Passos, W Winkelmann, WJ Jeffcoate, WS Maxson, Y Greenman   +131 more
core   +1 more source

ACT001 Inhibits Tumor Progression and Modulates Immune Responses in Non‐Small Cell Lung Cancer

Journal of Clinical Laboratory Analysis, Volume 39, Issue 17, September 2025.
ACT001, a novel small‐molecule inhibitor, demonstrates significant antitumoral and immunomodulatory effects in NSCLC by inhibiting cell proliferation, migration, and invasion, inducing cell cycle arrest, and suppressing tumor growth. Mechanistically, it targets STAT1/STAT3, reduces PD‐L1 expression, and enhances granzyme B release in CD3+ T cells ...
Zhijing Shi, Yiman Li, Huijie Hou, Zhitao Wang, Hui Guo, Yang Yu, Yan Song, Zhe Chen   +7 more
wiley   +1 more source

Transient elevated serum prolactin in trans women is caused by cyproterone acetate treatment [PDF]

, 2017
Purpose: Hormone treatment in trans women in Europe usually consists of the administration of estrogens and antiandrogens, for example, cyproterone acetate (CPA). Mild serum prolactin elevations during follow-up are attributed to estrogen therapy.
Defreyne, Justine, den Heijer, Martin, Fisher, Alessandra D, Nota, Nienke, Pereira, Cecilia, Schreiner, Thomas, T'Sjoen, Guy   +6 more
core   +2 more sources

Multifunctional Bone Morphogenetic Protein System in Endocrinology [PDF]

, 2013
New biological activities of bone morphogenetic proteins (BMPs) in the endocrine system have recently been revealed. The BMP system is composed of approximately 30 ligands and preferential combinations of type I and type II receptors.
Otsuka, Fumio
core   +1 more source

Long-term cardiac (valvulopathy) safety of cabergoline in prolactinoma

Indian Journal of Endocrinology and Metabolism, 2017
Background: Clinical relevance of association of cabergoline use for hyperprolactinemia and cardiac valvulopathy remains unclear. Objective: The aim of the study was to determine the prevalence of valvular heart abnormalities in patients taking ...
Shruti Khare, Anurag R Lila, Rishikesh Patil, Milind Phadke, Prafulla Kerkar, Tushar Bandgar, Nalini S Shah   +6 more
doaj   +1 more source