Results 61 to 70 of about 10,516 (266)

Discordance Between Prolactinoma Size and Prolactin Level: An Unusual Laboratory Finding [PDF]

, 2021
Wafa Dawaher, Sabah Patel, Zubina Unjom, Alvia Moid, Janice L Gilden, Victoria Trendafilova   +5 more
openalex   +1 more source

DRD2 Deficiency Underlies Pituitary Adenoma Dependent on Escherichia coli Translocation from the Gut

Advanced Science, Volume 13, Issue 24, 27 April 2026.
Dopamine receptor D2 (DRD2) deficiency disrupts epithelial barrier integrity in both the gut and pituitary gland, facilitating translocation of gut‐derived Escherichia coli into pituitary tissue. Intratumoral E. coli are phagocytosed by microglia, triggering GSDMD‐dependent pyroptosis and HMGB1 release, which subsequently activates MAPK signaling to ...
Xian‐jun Su, Li Ma, Xi Xiong, Jun‐hua Meng, Qi Wu, Yu Zhang, Shu‐guang Dong, Yue‐fei Wang, Jin‐hu Wu, Qing‐yuan Zeng, Hong‐feng Zhang, Li‐li Li, Liang Meng, Min Peng, Xiao‐dong Huang, Li‐quan Wu, Xiong Wang   +16 more
wiley   +1 more source

Prolactinoma: Medical and Surgical Considerations

, 2022
Prolactinomas are the most common secretory tumor of the pituitary gland. Clinical symptoms may be due to prolactin oversecretion, localized mass effect, or a combination of both.
Rock, Jack P, Haider, Sameah A, Craig, John R, Levy, Shiri   +3 more
core  

Anti-EGFL7 antibodies inhibit rat prolactinoma MMQ cells proliferation and PRL secretion

Open Chemistry, 2018
Prolactinoma is the most frequently diagnosed pituitary tumors. Dopamine agonists (DAs) are recognized as first-line therapy; however, approximately 10% patients will develop resistance to DAs therapy.
Liu Qian, Yuan Taoyang, Gao Hua, Gui Songbai, Zhang Yazhuo, Li Chuzhong   +5 more
doaj   +1 more source

Very Long‐Term Follow‐Up of Multidimensional Health‐Related Quality of Life After Endoscopic Endonasal Surgery for Pituitary Adenomas: A Prospective Cohort Study

Head &Neck, Volume 48, Issue 4, Page 1088-1096, April 2026.
ABSTRACT Background To evaluate postoperative health‐related quality of life (HRQoL) for pituitary adenoma patients, multidimensional assessment is important. Available data is limited on long‐term follow‐up. Methods Prospectively, 52 nonfunctioning (NFA) and functioning (FA) pituitary adenoma patients were included.
Gonneke E. Joustra, Nathalie F. van Rhee, Marc C. den Heijer, Astrid G. W. Korsten‐Meijer, Robert A. Feijen, György B. Halmos, Jos M. A. Kuijlen, Karin M. Vermeulen   +7 more
wiley   +1 more source

Patients With Pituitary Neuroendocrine Tumours Requiring Neurosurgery –Who Is Referring Them?

Clinical Endocrinology, Volume 104, Issue 4, Page 352-361, April 2026.
ABSTRACT Objective Patients living with pituitary neuroendocrine tumours (PitNETs) present with a spectrum of clinical manifestations and often follow a circuitous route to diagnosis, resulting in diagnostic delays. The objective of this study is to identify and report the various sources of referrals for patients who underwent pituitary resection for ...
Doua S. Ahmed, Brian Herron, Stephen Cooke, Philip Weir, Jane Evanson, Estelle G. Healy, Karen R. Mullan, Stephanie G. Craig, Jacqueline A. James, Márta Korbonits, Steven J. Hunter, Paul Benjamin Loughrey   +11 more
wiley   +1 more source

NR3C1 Modulates Wnt Signalling to Influence the Invasiveness and Immune Features of Nonfunctioning Invasive Pituitary Adenomas

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Pituitary adenomas (PAs) are common intracranial tumours, and invasiveness in nonfunctioning invasive pituitary adenomas (NIPAs) predicts poor prognosis. The molecular mechanisms driving this phenotype remain unclear. This study explored the role of nuclear receptor subfamily 3 group C member 1 (NR3C1) in NIPA invasiveness and its regulation ...
Xiaoping Wang, Jinfeng Zhang, Tao Jiang, Zhijun Yang, Yu Zhang, Pinan Liu, Yuanxiang Lin   +6 more
wiley   +1 more source

Ept7, a quantitative trait locus that controls estrogen-induced pituitary lactotroph hyperplasia in rat, is orthologous to a locus in humans that has been associated with numerous cancer types and common diseases. [PDF]

PLoS ONE, 2018
Pituitary adenoma is a common intracranial neoplasm that is observed in approximately 10% of unselected individuals at autopsy. Prolactin-producing adenomas, i.e., prolactinomas, comprise approximately 50% of all pituitary adenomas and represent the most
Kirsten L Dennison, Aaron C Chack, Maureen Peters Hickman, Quincy Eckert Harenda, James D Shull   +4 more
doaj   +1 more source

The emerging role of chemokines and chemokine receptors in the biological and clinical behaviour of pituitary neuroendocrine tumours: An exploratory transcriptomic study

Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.
Abstract The chemokine network in the microenvironment of pituitary neuroendocrine tumours (PitNETs) may modulate tumour biology, aggressiveness, and treatment responses. We aimed to study the role of various chemokines and chemokine receptors in defining PitNET phenotype and clinical outcomes.
Ana Luísa Silva, Sayka Barry, Ana Hipólito, Mariana de Griné Severino, Rita Joaquim, Charlotte Hall, Tiago Oliveira, Dolores López‐Presa, Gonçalo Borrecho, Francisco Tortosa, Ema Nobre, Claudia C. Faria, Márta Korbonits, Pedro Marques   +13 more
wiley   +1 more source

The PKA/MBD2 Axis Transcriptionally Represses INPP5A to Modulate PI3K/Akt Signaling and Accelerate Pituitary Tumorigenesis

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Loss of INPP5A in PitNETs disrupts IP3 clearance and drives aberrant PI3K/Akt activation. PKA‐dependent phosphorylation stabilizes MBD2 via 14‐3‐3σ, sustaining transcriptional silencing of INPP5A. MBD2 inhibition sensitizes tumors to standard treatments and limits PitNET growth.
Qian Jiang, Yaorui Wang, Zihan Wang, Quanji Wang, Sihan Li, Linpeng Xu, Zhuo Zhang, Zhoubin Tan, Huaqiu Zhang, Kai Shu, Ting Lei, Yimin Huang, Zhuowei Lei   +12 more
wiley   +1 more source