Results 101 to 110 of about 455,569 (249)

Zeb2 Controls Retinal Physiological and Pathological Angiogenesis by Regulating Astrocyte Proliferation and Differentiation

Cell Proliferation, EarlyView.
During development, the oxygen‐sensitive transcription factor Zeb2 restrains astrocyte proliferation and maturation to ensure balanced retinal angiogenesis. In disease, it promotes the neurotoxic A1 astrocyte phenotype and inflammation, thereby promoting reparative revascularization over pathological neovascularization.
Jing Liu, Yanan Guo, Kangjian Xiang, Shuyi Wang, Dongchang Xiao, Mengqing Xiang   +5 more
wiley   +1 more source

Targeting CKIP‐1 for Disease Therapy: Cellular Functions, Molecular Networks, and Clinical Potential

Cell Proliferation, EarlyView.
CKIP‐1, as a scaffold protein with special structural domains, treats related diseases through multiple emerging targeted technologies.
Xin Huang, Shijie Lv, Lejia Li, Jirong Xie, Zhengguo Cao   +4 more
wiley   +1 more source

Efficacy and Safety of SGLT2 Inhibitors in Patients With Genetic Lipodystrophy: A Real‐Life Experience From a National Reference Network

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim Lipodystrophy syndromes are rare diseases with metabolic and cardiovascular consequences. This study explores the metabolic and renal effects of sodium‐glucose cotransporter 2 inhibitors (SGLT2i) in patients with genetic lipodystrophy. Patients and Methods Patients with familial partial lipodystrophy (n = 57) or congenital generalised ...
Léna Robert, Ines Belalem, Corinne Vigouroux, Hippolyte Dupuis, Marie Christine Vantyghem, Mathilde Simonson, Estelle Nobecourt, Héléna Mosbah, Sophie Beliard, Stéphanie Jellimann, Sonja Janmaat, Camille Vatier, Sophie Lamothe   +12 more
wiley   +1 more source

Ocular Manifestations of Metabolic Syndrome: A Systemic Vascular Phenotype

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Context Metabolic syndrome (MetS) is defined by central obesity, insulin resistance, hypertension and dyslipidemia. MetS affects over one‐third of US adults. Beyond its cardiovascular burden, MetS has clinically relevant associations with ocular health and may contribute to a systemic vascular and neuro‐metabolic phenotype involving the retina,
Ron T. Varghese, Ansu A. John
wiley   +1 more source

Multimodal Exploratory Analysis of Persistent Diabetic Macular Edema: Integrating Aqueous Humour Metabolomics, Clinical and OCT Features

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Purpose This exploratory study integrates aqueous humour metabolomic data with clinical and imaging features to examine candidate biomarkers and characterize multimodal patterns associated with persistent diabetic macular edema (pDME). Methods In this prospective cohort study, DME patients were treated with monthly anti‐VEGF injections over 3 ...
Yunhan Tao, Huimin Yu, Yunxi Ma, Mingzhu Yuan, Guochong Chen, Jun Liu, Xi Chen, Xufang Sun   +7 more
wiley   +1 more source

Prevalence of diabetic retinopathy at Parirenyatwa hospital

, 2019
BACKGROUND: There is a global epidemic of diabetes mellitus. Diabetes mellitus causes a myriad of microvascular and macrovascular complications. Diabetic retinopathy is one of the main microvascular complications. It is preventable.
Maboreke, Nyasha Phanuel
core  

Therapies for Cardiovascular‐Kidney‐Liver‐Metabolic Syndrome: Reappraisal of Fibrates

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Cardiovascular disease, chronic kidney disease (CKD), type 2 diabetes mellitus (T2DM), obesity and metabolic dysfunction‐associated steatohepatitis (MASH) frequently coexist and share overlapping pathophysiology, forming the proposed cardiovascular‐kidney‐liver‐metabolic (CKLM) syndrome.
Virginia Anagnostopoulou, Christoforos K. Travlos, Lucas Lage Marinho, Thomas A. Mavrakanas, João Pedro Ferreira, Abhinav Sharma   +5 more
wiley   +1 more source

Omnipod 5 Delivers Superior Economic Value Compared to Multiple Daily Injections: A Cost‐Effectiveness Analysis in Adults With T1D From a Payer Perspective in Sweden

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim Analyse the cost‐effectiveness of the Omnipod 5 automated insulin delivery system versus multiple daily injections (MDI) with continuous glucose monitoring for type 1 diabetes among adults in Sweden. Methods Cost‐effectiveness was analysed with the IQVIA Core Diabetes Model (version 10.0) taking the perspective of the payer in Sweden ...
Johan Jendle, Colin Hopley, Anuj Narang, Raffaele Scarica, Helena Hellerstedt, Melanie Littlewood   +5 more
wiley   +1 more source

Comparing the Axial Length of Eyes in Patients with Proliferative and Non-proliferative Diabetic Retinopathy

مجله دانشکده پزشکی اصفهان, 2011
Background: Diabetic retinopathy occurs in the retina due to changes in blood vessels. It may cause fluid or blood leakage and fragile vascular bundles which make the sent image to the brain blurry. About half of patients with diabetes mellitus have some
Farhad Fazel, Heshmatollah Ghanbari, Saeed Saghaee   +2 more
doaj  

Ten‐Year Cost‐Effectiveness of the Risk Assessment and Management Programme—Diabetes Mellitus (RAMP‐DM) Relative to Usual Care in Hong Kong Public Primary Care: A Population‐Based Cohort Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims The Risk Assessment and Management Programme—Diabetes Mellitus (RAMP‐DM) is a multidisciplinary, protocol‐driven, risk‐stratified care model integrated into public primary care in Hong Kong for patients with type 2 diabetes mellitus (T2DM).
Eric Ho Man Tang, Ivy Lynn Mak, Emily Tsui Yee Tse, Esther Yee Tak Yu, Julie Yun Chen, Weng Yee Chin, David Vai Kiong Chao, Wendy Wing Sze Tsui, Tony King Hang Ha, Carlos King Ho Wong, Cindy Lo Kuen Lam, Eric Yuk Fai Wan   +11 more
wiley   +1 more source