Results 161 to 170 of about 303,245 (307)

A Unifying Thermodynamic Model for Phase Separation and Aging of Biopolymers

Advanced Science, EarlyView.
Phase separation and aging of intrinsically disordered proteins are placed in a unifying framework. A thermodynamically consistent time‐dependent version of associating‐polymer theory shows how the processes are intricately coupled. Assuming aging to occur through interacting sites resulting from reversible conformational transitions, the model ...
Jasper J. Michels, Joana Caria, Edward A. Lemke   +2 more
wiley   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

Proline Ring-Inversion Dynamics in Peptides Enable Cross-Relaxation-Based Dynamic Nuclear Polarization. [PDF]

Chemphyschem
Taube F, Gierth M, Künze G, Corzilius B.   +3 more
europepmc   +1 more source

Adaptive Responses of Tropical Crops: A Multi‐Scale Omics Integrated Perspective

Advanced Science, EarlyView.
Tropical crops integrate genomic, morphological, physiological, and ecological adaptations to thrive under extreme and variable environments. This review highlights how natural selection, domestication, and breeding shape stress resilience, resource‐use strategies, and productivity in sugarcane, banana, cassava, rubber and oil palm, offering new routes
Peilin Wang, Chenhui Li, Dongjiao Wang, Qibin Wu, Zhen Zeng, Huiming Guo, Han Cheng, Songbi Chen, Hongxing Cao, Hongmei Cheng, Jianghui Xie, Youxiong Que   +11 more
wiley   +1 more source

Harnessing the thermotolerant methylotroph Bacillus methanolicus for methanol-based synthetic L-proline production. [PDF]

Microb Cell Fact
Frank C, Virant D, Kosec G, Hoffmann T, Zelder O, Felle MF, Bremer E.   +6 more
europepmc   +1 more source

Trafficking Deficiency of TMEM175 Variants in Parkinson's Disease Pathogenesis and the Prospects of Precision Medicine

Advanced Science, EarlyView.
This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo, Yu He, Shuyao Li, Haoyu Guan, Ruili Cui, Yu Shi, Zhongwen Jiang, Siyu Wang, Xuan Li, Jiyuan Li, Mei Hu, Yupeng Zhou, Beisha Tang, Yanyan Zhang, Zhaobing Gao, Yu Zhou, Zhenhua Liu, Ping Li   +17 more
wiley   +1 more source

Cancer stem cells synthesize proline to attenuate oxidative stress. [PDF]

J Clin Invest
Wu W, Zhang P, Wang D, Wu X, Wu Q, Li D, Huang T, Wang R, Li H, Mi H, Taori S, Yuan F, Duan T, Chen Z, Yuan H, Rich JN.   +15 more
europepmc   +1 more source

Deep Learning Prediction of O‐Glycopeptide Tandem Mass Spectra Enhances O‐Glycoproteomics

Advanced Science, EarlyView.
DeepGPO integrates Transformer and graph neural networks with tailored training strategies, including data augmentation, loss re‐weighting, and pre‐training, to achieve high‐quality O‐glycopeptide MS/MS spectra prediction. The predicted MS/MS spectra are used to localize O‐glycosylation sites from HCD MS/MS data, enhancing O‐glycoproteomics analysis ...
Yu Zong, Yuxin Wang, Liang Qiao
wiley   +1 more source

Dysregulated Proline Metabolism Exacerbates Hepatocellular Carcinoma Metastasis via EPRS1-Mediated mRNA Translation. [PDF]

Cancer Commun (Lond)
Zhang H, Gu L, Su X, Chen W, Tan M, Yu H, Zhou H, Gao T, Wang Z, Chen X, Chen W, Chen J, Cheng S.   +12 more
europepmc   +1 more source

Rational Design of π‐Conjugated Polymers for Enantioselective Recognition of Amino Acids

Advanced Electronic Materials, EarlyView.
A family of conducting polymers is proposed for the enantioselective recognition of amino acids. The films are generated by electropolymerization of thiophene trimers containing chiral features, with the advantage that the polymerization can be induced at much lower overpotentials compared to classic thiophene monomers, thus avoiding parasitic ...
Gerardo Salinas, Rana Nakar, Getnet Kassahun, Matthieu Raoux, Jochen Lang, Damien Thuau, Mamatimin Abbas, Eric Cloutet, Alexander Kuhn   +8 more
wiley   +1 more source