Results 181 to 190 of about 303,245 (307)

Beyond the Fixed Charge: A New On‐Tissue Derivatisation Strategy Employing Photoionisable Chromophores for Mass Spectrometry Imaging of Amino‐Containing Metabolites

Angewandte Chemie, EarlyView.
We introduce a novel chemical derivatisation strategy for the UV‐activated detection of elusive metabolites. Incorporation of a tocopherol‐active chromophore allows for the detection of tagged analytes as photoionised radical cations, selectively induced by a 266 nm laser.
Sofia R. McGowan, Andrew J. Tague, Ashna A. Kumar, Marie Ranson, Christopher J. T. Hyland, Shane R. Ellis   +5 more
wiley   +2 more sources

FeSseqdb: a curated sequence-level database and interpretable machine learning framework for identifying iron-sulfur proteins. [PDF]

BMC Bioinformatics
Min J, Brooks BR, Amin M.
europepmc   +1 more source

Refining Domain‐Based Prognostication in DNM1 Encephalopathy: A Mild Phenotype Associated With a GTPase Domain Variant

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT DNM1 encephalopathy is a rare autosomal dominant genetic condition characterized by a range of neurological and developmental manifestations. The typical phenotype is severe, including profound intellectual disability, treatment‐resistant epilepsy, ataxia, and structural brain abnormalities. However, milder presentations have increasingly been
Caroline Crain, Hope Northrup, Laura S. Farach, Sureni V. Mullegama, Kathleen Shields, Gretchen Von Allmen, Kate Richardson   +6 more
wiley   +1 more source

Heat-Stress Memory Modulates Antioxidant Metabolism and Increases Senecionine Biosynthesis Across Developmental Stages of <i>Senecio madagascariensis</i>. [PDF]

Plants (Basel)
Heck T, Souza GM, Posso DA, Zuñiga RMP, Avila L.   +4 more
europepmc   +1 more source

Underexplored Catalysts as General Structures: Application of Machine Learning Techniques for Reaction‐Specific Datasets

Angewandte Chemie, EarlyView.
Bias‐aware machine learning identified an underexplored imidazolidinone catalyst with broad competitive performance in iminium‐based reactions. Experimental benchmarking shows how data‐driven prioritization can uncover overlooked catalyst scaffolds from sparse and historically biased literature data.
Jiajing Li, Isaiah O. Betinol, Junshan Lai, Soresu Juyo, Jolene P. Reid   +4 more
wiley   +2 more sources

Proline-promoted electrophilic dichloromethylation of α-enaminones via stereochemically gated resolution. [PDF]

Nat Commun
Kuniavsky E, Levy DR, Tsvelikhovsky D.
europepmc   +1 more source

Distribution of Big Tau Isoforms in the Human Central and Peripheral Nervous System

Annals of Neurology, EarlyView.
Objective Tau is widely studied in neurodegeneration, yet most work has focused on canonical brain tau isoforms. A longer isoform, “big tau,” produced by inclusion of exon 4a, is expressed in the peripheral nervous system (PNS) and central nervous system (CNS) regions.
Rama Krishna Koppisetti, Nicolas R. Barthélemy, Kanta Horie, Cindy V. Ly, Kaleigh F. Roberts, Srinivas Koutarapu, Richard J. Perrin, Erin E. Franklin, Chiara Pedicone, Joshua Orrick, Justin Melendez, Timothy M. Miller, Chihiro Sato, Nupur Ghoshal, Alison M. Goate, Celeste M. Karch, Randall J. Bateman, Soumya Mukherjee   +17 more
wiley   +1 more source

Combined Histidine and Proline Supplementation (HISPRO) Enhances Oxidative and Mitochondrial Function in Skeletal Muscle Through SIRT1-Associated Signaling. [PDF]

Cells
Lee D, Jeon J, Huh G, Baek S, Kim D, Kang HJ, Lee H, Lee IK, Jeon JH, Jung HY.   +9 more
europepmc   +1 more source

Electron Beam-Degraded β-Glucans from <i>P. ostreatus</i> Retain Their Structure and Biological Activity. [PDF]

Polymers (Basel)
Lyutova Z, Dozortseva A, Manurikov Y, Markova M, Mazur A, Khaleev V, Arutyunyan A, Borisenkova A.   +7 more
europepmc   +1 more source

Evaluation of metabolite biomarker candidates in detecting HCC in patients with liver cirrhosis. [PDF]

Metabolomics
Rashid MM, Varghese RS, Sajid MS, Sherif ZA, Kroemer A, Ressom HW.   +5 more
europepmc   +1 more source