Results 191 to 200 of about 583,561 (341)

Antinociceptive and antidepressant-like action of endomorphin-2 analogs with proline surrogates in position 2

, 2014
Renata Perlikowska, Justyna Piekielna‐Ciesielska, Marzena Mazur, Robert Koralewski, Jacek Olczak, Jean‐Claude do Rego, Jakub Fichna, Jakub Modranka, Tomasz Janecki, Anna Janecka   +9 more
openalex   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Targeting the Proline-Rich Tyrosine Kinase 2 /Mitochondrial Calcium Uniporter Pathway, Ruthenium Red, and Nimodipine alone and in Combination Evoked Neuroprotective Effect in Experimentally Induced Brain Stroke in Rats

, 2020
Amany A. Alzokaky
openalex   +1 more source

Osteoarthritis Linked to Diabetes Characterized Sharp Decreasing in Ser / Proline /PLC?2 with Increasing PLC?1, Where Inhibiting S6K/BTK / PLC?2 Affect TXA2 Synthesis Cause C-Lymphocytic Leukemia

, 2022
Ashraf Marzouk El Tantawi
openalex   +1 more source

Host‐Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules

Advanced Science, EarlyView.
Amid the ongoing threat of emerging viral pathogens, host‐directed antivirals offer a strategy to overcome viral mutation and drug resistance. SB2960, a small‐molecule inducer of stress granules (SGs), exhibits potent broad‐spectrum antiviral activity with minimal cytotoxicity.
Wan Gi Byun, Sumin Son, JinAh Lee, Minha Lee, Meehyun Ko, Songrui Zhao, Ju Hee Kim, Kannan Vaithegi, Ji Hoon Kwon, Jung Ho Lee, Sangeun Jeon, Dawon Yi, Peng Zou, Seungtaek Kim, Seung Bum Park   +14 more
wiley   +1 more source

The effect of salicylic acid and jasmonic acid solution spray on soluble sugar, proline and enzymes of lavender (Lavendula officinalis L.) under salt stress. [PDF]

, 2018
Fereshte Rezaee Nasab, Alireza Pazoki, Reza Monaem   +2 more
openalex   +1 more source

Proline as a Sparker Metabolite of Oxidative Metabolism during the Flight of the Bumblebee, Bombus impatiens [PDF]

, 2021
Nadia Stec, Ammar Saleem, Charles-A. Darveau   +2 more
openalex   +1 more source

Integrative Multi‐Omics Analysis Uncovers Immunological Phenotypes Predictive of Combinatorial Immunotherapy Response in Gastric Cancer

Advanced Science, EarlyView.
Current understanding of gastric cancer immunity remains inadequate, leading to suboptimal immunotherapy outcomes. This study introduces a novel tumor immune microenvironment classification system (Inflamed, Desert, and Excluded), advancing traditional histopathological or molecular subtyping toward a functional immunological framework.
Jianchao Wang, Wenfang Zhang, Jiyang Zhang, Chenhui Zhao, Wei Zhang, Menghan Fang, Fangfang Chen, Zhida Wu, Xiaoya Xu, Ziqing Yu, Qiong Zhu, Yi Shi, Dadong Zhang, Xiaofeng Chen, Gang Chen   +14 more
wiley   +1 more source

Identification of a Novel Polyproline Recognition Site in the Cytoskeletal Associated Protein, Proline Serine Threonine Phosphatase Interacting Protein [PDF]

, 1998
Donald Dowbenko, Susan D. Spencer, Clifford Quan, Laurence A. Lasky   +3 more
openalex   +1 more source

Principles for Rigorous Design and Application of Synthetic Microbial Communities

Advanced Science, EarlyView.
SynComs are artificially designed to enable inter‐species metabolic interactions, metabolic division of labor, and ecological interactions that can elicit phenotypes like colonization stability and environmental adaptation. This systematic review explores the processes used to construct SynComs, the assessment of the mechanisms of metabolic interaction
Yuxiao Zhang, Minyu Jing, Lihui Lyu, Li Nie, Xihui Xu, Ru Sun, Xiyuan Xu, Siyu Chen, Shuobing He, Yumeng Zhang, Ping Huang, Weijie Luo, Jiaojiao Liang, Guifeng Gao, Kunkun Fan, Teng Yang, Liyan Zhang, Xiao Fu, Sarah M. Allard, Jack A. Gilbert, Jiabao Zhang, Haiyan Chu   +21 more
wiley   +1 more source