Results 221 to 230 of about 583,561 (341)

The Gut Commensal Butyricimonas Virosa Modulates Gut Microbiota‐Dependent Thiamine Metabolism and Attenuates Mouse Steatotic Liver Disease

Advanced Science, EarlyView.
This study reveals that dietary stachyose enriches Butyricimonas virosa, effectively attenuating metabolic dysfunction‐associated steatotic liver disease (MASLD). Mechanistically, B. virosa enhances gut thiamine monophosphate synthesis, which elevates hepatic thiamine pyrophosphate levels.
Ningning He, Haoyu Wang, Zizhen Yang, Hui Li, Bei Liu, Kaiwei Chen, Zhinan Wu, Xinnan Zhao, Hewei Liang, Mengmeng Wang, Xiaofang Li, Yiyi Zhong, Haifeng Zhang, Liang Xiao, Karsten Kristiansen, Jixing Peng, Yuanqiang Zou, Shangyong Li   +17 more
wiley   +1 more source

Consumption of L-Proline as Energy Substrate by Cultured Primary Rat Astrocytes. [PDF]

Neurochem Res
Spellerberg P, Dringen R.
europepmc   +1 more source

Structure‐Guided Engineering of a Promiscuous O‐Methyltransferase for a SAM Regeneration Biocatalysis Platform of Methylated Pharmaceuticals

Advanced Science, EarlyView.
A substrate promiscuous and regioselective O‐methyltransferase, SmOMT, is functionally and structurally characterized. A double mutant, SmOMTE152A/I306A, exhibited enhanced catalytic activity. By coupling this mutant with a mutant halide methyltransferase, AtHMTV140T, for SAM regeneration, a superior artificial fusion enzyme, AtHMTV140T‐L95‐SmOMTE152A ...
Xiran Xiong, Jun Song, Shihan Li, Lu Jin, Qi He, Baohui Zhang, Yan Cao, Shanyong Yi, Yanfang Yang, Xiang Li, Juan Li, Wei Huang   +11 more
wiley   +1 more source

Cryopreservation technology for improving the stability of liposomes and its precise drug monitoring in clinical drug research. [PDF]

Drug Deliv
Boafo GF, Shaw I, Ekpo MD, Wang L, Ali YS, Tan S, Zhu Z, Wang R, Chen C, Zheng H.   +9 more
europepmc   +1 more source

Kinetic investigation of human dipeptidyl peptidase II (DPPII)-mediated hydrolysis of dipeptide derivatives and its identification as quiescent cell proline dipeptidase (QPP)/dipeptidyl peptidase 7 (DPP7)

, 2005
Marie-Berthe Maes, Anne‐Marie Lambeir, Kambiz Gilany, Kristel Senten, Pieter Van der Veken, Barbara Leiting, Koen Augustyns, Simon Scharpé, Ingrid De Meester   +8 more
openalex   +1 more source

AI‐Based D‐Amino Acid Substitution for Optimizing Antimicrobial Peptides to Treat Multidrug‐Resistant Bacterial Infection

Advanced Science, EarlyView.
This study constructed the first D‐amino acid antimicrobial peptide dataset and developed an AI model for efficient screening of substitution sites, with 80% of candidate peptides showing enhanced activity. The lead peptide dR2‐1 demonstrated potent antimicrobial activity in vitro and in vivo, high stability, and low toxicity.
Yinuo Zhao, Qingzhou Kong, Haifan Gong, Lixiang Li, Jialu Fu, Boyao Wan, Peizhu Wang, Xiaojuan Li, Yue Wang, Jinghui Zhang, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +14 more
wiley   +1 more source

Multi-omics analysis reveals a protective role of endogenous proline in sheep oocyte vitrification and its therapeutic application. [PDF]

Front Cell Dev Biol
Dilixiati A, Zhao X, Aihemaiti A, Li W, Fan C, Zhao G, Wusiman A, Wang X.   +7 more
europepmc   +1 more source

A concise and practical stereoselective synthesis of ipragliflozin L-proline [PDF]

, 2017
Shuai Ma, Zhenren Liu, Jing Pan, Shunli Zhang, Weicheng Zhou   +4 more
openalex   +1 more source

Nanozymes Integrated Biochips Toward Smart Detection System

Advanced Science, EarlyView.
This review systematically outlines the integration of nanozymes, biochips, and artificial intelligence (AI) for intelligent biosensing. It details how their convergence enhances signal amplification, enables portable detection, and improves data interpretation.
Dongyu Chen, Wang Zheng, Zhihui Zhang, Shenping Yu, Xinxin Hang, Han Wu, Xiao‐Wei Xiang, Wei Mu, Yanli Jiao, Zaizai Dong, Lingqian Chang   +10 more
wiley   +1 more source

Coordinated physiological and molecular reprogramming by brassinosteroids improves soybean tolerance to combined salt and drought stress. [PDF]

Plant Signal Behav
Khan TA, Saeed T, Tran LSP, Gururani MA.
europepmc   +1 more source