Results 261 to 270 of about 303,245 (307)
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Applied Biochemistry and Biotechnology, 2022
D-proline and N-boc-5-hydroxy-L-proline are key chiral intermediates in the production of eletriptan and saxagliptin, respectively. An efficient proline racemase-proline dehydrogenase cascade was developed for the enantioselective production of D-proline.
Fanfan Zhang +4 more
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D-proline and N-boc-5-hydroxy-L-proline are key chiral intermediates in the production of eletriptan and saxagliptin, respectively. An efficient proline racemase-proline dehydrogenase cascade was developed for the enantioselective production of D-proline.
Fanfan Zhang +4 more
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Supported proline and proline-derivatives as recyclable organocatalysts
Chemical Society Reviews, 2008In the last eight years, L-proline and L-proline derivatives, such as substituted prolinamides or pyrrolidines, have been successfully used as organocatalysts in several reactions. In this critical review we summarize the immobilization procedures of such organocatalysts highlighting their application, recoverability and reusability (86 references).
GRUTTADAURIA, Michelangelo +2 more
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Proline metabolism in cartilage: The importance of proline biosynthesis
Metabolism, 1978Abstract Mammalian cells have the capacity to synthesize proline from ornithine or glutamic acid, although preformed proline usually is available from extracellular sources. We have measured the rate of proline formation from ornithine in the presence of physiologic concentrations of proline. In rat xiphoid cartilage organ cultures with ornithine and
R J, Smith, J M, Phang
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Chemical Reviews
Within the canonical repertoire of the amino acid involved in protein biogenesis, proline plays a unique role as an amino acid presenting a modified backbone rather than a side-chain. Chemical structures that mimic proline but introduce changes into its specific molecular features are defined as proline analogues.
Vladimir Kubyshkin, Marina Rubini
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Within the canonical repertoire of the amino acid involved in protein biogenesis, proline plays a unique role as an amino acid presenting a modified backbone rather than a side-chain. Chemical structures that mimic proline but introduce changes into its specific molecular features are defined as proline analogues.
Vladimir Kubyshkin, Marina Rubini
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Mechanism-based inhibition of proline dehydrogenase by proline analogues
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1993The inactivation of proline dehydrogenase by several L-Pro analogues was investigated with the aim to block the essential metabolic pathway of tsetse flies allowing the degradation of L-Pro to L-Glu. In vitro studies on rat liver mitochondria showed that only 4-methylene-L-proline was able to inactivate proline dehydrogenase.
D, Tritsch, H, Mawlawi, J F, Biellmann
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Proline incorporation into the proline and hydroxyproline of earthworm-cuticle collagen
Biochimica et Biophysica Acta (BBA) - General Subjects, 1965Abstract Studies in vivo of the incorporation of proline into earthworm cuticle have shown that, as with vertebrate collagens, proline and not free hydroxyproline is the source of both proline and hydroxyproline in cuticle collagen. Purified salt-soluble cuticle collagen preparations contain a component highly labeled in proline and resistant to ...
D, Fujimoto, E, Adams
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Effect of Dietary Proline on Proline Metabolism in the Neonatal Pig
The Journal of Nutrition, 1989The effect of two dietary concentrations of proline (10.3 and 15.8 g/kg) on proline-metabolizing enzymes [pyrroline-5-carboxylate (P5C) reductase and proline oxidase], plasma and tissue free proline concentrations and growth were investigated in the 2- to 13-d-old pig. Diet had no effect on growth or enzyme activity. Diet had a significant (P less than
S E, Samuels, H L, Aarts, R O, Ball
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Plasma proline kinetics and the regulation of proline synthesis in man
Metabolism, 1987A quantitative exploration of the regulation of plasma proline concentration, proline oxidation, and proline endogenous biosynthesis was undertaken utilizing a 360-minute primed continuous infusion of L-[1-13C]proline and L-[methyl-2H3]leucine in healthy, postabsorptive young men.
T, Jaksic +3 more
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Fasciolicidal potential of proline analogues and proline biosynthesis inhibitors
International Journal for Parasitology, 1982Abstract Sheers Marion , Campbell Anne J. , Beames D. J. , Edwards S. R. , Moore R. J. and Montague P. E. 1982. Fasciolicidal potential of proline analogues and proline biosynthesis inhibitors. International Journal for Parasitology 12 : 47–52.
M, Sheers +5 more
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Proline and hepatic lipogenesis
Biochimica et Biophysica Acta (BBA) - General Subjects, 1984The effects of proline on lipogenesis in isolated rat hepatocytes were determined and compared with those of lactate, an established lipogenic precursor. Proline or lactate plus pyruvate increased lipogenesis (measured with 3H2O) in hepatocytes from fed rats depleted of glycogen in vitro and in hepatocytes from starved rats.
M C, Sugden +3 more
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