Results 221 to 230 of about 218,823 (239)
Some of the next articles are maybe not open access.
Epoxide derivatives of pipecolic acid and proline are inhibitors of pipecolate oxidase
Bioorganic & Medicinal Chemistry Letters, 1998The cis-4,5-epoxide derivative of L-pipecolic acid (2S,4S,5R-epoxypipecolic acid, cis-3) was synthesized and found to serve as an excellent substrate for L-pipecolate oxidase (L-PO) and also to cause time-dependent, irreversible inactivation of the enzyme. Data are presented showing this compound is a mechanism-based inhibitor of L-PO, whereas 2S,3R,4S-
B, Ho, T M, Zabriskie
openaire +2 more sources
Identification of a p53-response element in the promoter of the proline oxidase gene
Biochemical and Biophysical Research Communications, 2008Proline oxidase (POX) is a p53-induced proapoptotic gene. We investigated whether p53 could bind directly to the POX gene promoter. Chromatin immunoprecipitation (ChIP) assays detected p53 bound to POX upstream gene sequences. In support of the ChIP results, sequence analysis of the POX gene and its 5' flanking sequences revealed a potential p53 ...
Steve A, Maxwell, Gerald J, Kochevar
exaly +3 more sources
The Journal of Parasitology, 1974
The source was sought for the high levels of proline observed in the bile of animals infected with Fasciola hepatica. Toward this end the activities of 2 key enzymes in the metabolism of proline were measured. Ornithine-4-transaminase was compared in homogenates of Fasciola, rabbit liver, and rat liver.
J, Ertel, H, Isseroff
openaire +2 more sources
The source was sought for the high levels of proline observed in the bile of animals infected with Fasciola hepatica. Toward this end the activities of 2 key enzymes in the metabolism of proline were measured. Ornithine-4-transaminase was compared in homogenates of Fasciola, rabbit liver, and rat liver.
J, Ertel, H, Isseroff
openaire +2 more sources
Pyrroline-5-Carboxylate Reductase and Proline Oxidase Activity in the Neonatal Pig
The Journal of Nutrition, 1989Recent evidence suggests that proline is an indispensible amino acid in the diet of the young pig. A dietary requirement may relate to the activity and developmental changes of the enzymes that synthesize and degrade proline. The activity of pyrroline-5-carboxylate (P5C) reductase (EC 1.5.1.2), which catalyzes the final step in proline synthesis, and ...
S E, Samuels, K S, Acton, R O, Ball
openaire +2 more sources
A radioisotopic assay for proline oxidase activity.
The Journal of laboratory and clinical medicine, 1975We developed a radioisotopic assay for proline oxidase in which product deltal-pyrroline-5-carboxylate-14-C is reacted with o-aminobenzaldehyde and the radioactivity trapped as the dihydroquinazolinium compound is recovered by ion-exchange chromatography.
J M, Phang +3 more
openaire +1 more source
Proline reduces brain cytochrome c oxidase: prevention by antioxidants
International Journal of Developmental Neuroscience, 2007AbstractIn the present study, we initially investigated the in vivo (acute and chronic) and in vitro effects of proline on cytochrome c oxidase (complex IV) activity in rat cerebral cortex to test the hypothesis that proline might alter energy metabolism and that this alteration could be provoked by oxidative stress.
Daniela, Delwing +4 more
openaire +2 more sources
Acta Physiologiae Plantarum, 1998
Calli of salt tolerant (Bhoora rata) and salt susceptible (GR11) rice varieties were cultured on Linsmaeir and Skoog’s medium containing LD50 concentration of NaCl (200 mM) and hydroxyproline (10 mM). Growth, proline content and activity of proline and IAA oxidases of the cultured tissues were determined at the end of 0, 2, 4, and 6 weeks of incubation.
Vyjayanti A. Chauhan, G. Prathapasenan
openaire +1 more source
Calli of salt tolerant (Bhoora rata) and salt susceptible (GR11) rice varieties were cultured on Linsmaeir and Skoog’s medium containing LD50 concentration of NaCl (200 mM) and hydroxyproline (10 mM). Growth, proline content and activity of proline and IAA oxidases of the cultured tissues were determined at the end of 0, 2, 4, and 6 weeks of incubation.
Vyjayanti A. Chauhan, G. Prathapasenan
openaire +1 more source
Cancer Research, 2012
Abstract A role for reactive oxygen species (ROS) in intracellular signaling has been generally accepted, but the organellar localization, the enzymatic source and the regulation of ROS generation are not well understood. Recent work by others has focused on mitochondria as a source of ROS and specifically on the reduction of oxygen by ...
Chad N. Hancock, James Phang
openaire +1 more source
Abstract A role for reactive oxygen species (ROS) in intracellular signaling has been generally accepted, but the organellar localization, the enzymatic source and the regulation of ROS generation are not well understood. Recent work by others has focused on mitochondria as a source of ROS and specifically on the reduction of oxygen by ...
Chad N. Hancock, James Phang
openaire +1 more source
Cancer research, 2001
The p53-dependent initiation of apoptosis is accompanied by the induction of proline oxidase (POX), a mitochondrial enzyme catalyzing the conversion of proline to pyrroline-5-carboxylate with the concomitant transfer of electrons to cytochrome c. However, the contribution of increased POX activity to apoptosis, if any, remains unknown. Using Adriamycin
S P, Donald +6 more
openaire +1 more source
The p53-dependent initiation of apoptosis is accompanied by the induction of proline oxidase (POX), a mitochondrial enzyme catalyzing the conversion of proline to pyrroline-5-carboxylate with the concomitant transfer of electrons to cytochrome c. However, the contribution of increased POX activity to apoptosis, if any, remains unknown. Using Adriamycin
S P, Donald +6 more
openaire +1 more source