Results 201 to 210 of about 218,823 (239)

Parallel and comparative transcriptome and proteome provide insight into degeneration-related key candidates in Agaricus bisporus. [PDF]

BMC Genomics
Lu Y, Zheng H, Ke B, Guo Z, Cai Z, Zeng Z, Chen W, Zeng H, Chen M.   +8 more
europepmc   +1 more source

Agro-physiological responses and molecular docking evaluation of some essential oils and ascorbic acid as eco-friendly inhibitors of powdery mildew in cucumber plants. [PDF]

Front Plant Sci
Omar HS, Mohamed A, El-Gammal NA, Omara RI, Ayad AA, El-Mogy MM, Williams LL, Abdeldaym EA.   +7 more
europepmc   +1 more source

Whole-plant spatiotemporal responses to salinity reveal osmotic and ionic drivers of salt tolerance in broccoli. [PDF]

BMC Plant Biol
Nicolas-Espinosa J, Guarnizo AL, Carvajal M, Yepes-Molina L.   +3 more
europepmc   +1 more source

Case Report: First report of a novel homozygous nonsense mutation in the <i>CYBA</i> gene causing chronic granulomatous disease. [PDF]

Front Immunol
Wang WY, Ma PP, Wang SY, Wang YJ.
europepmc   +1 more source

Identification of a candidate PRODH allosteric inhibitor MBTP-15324: modulation of proline metabolite profiles and ECM-associated gene-expression changes in lung cancer cells. [PDF]

J Enzyme Inhib Med Chem
Zhou Y, Bai D, Li Z, Li C, Li C, Chen M, Guo C, Yan J, Han Y, Yang Q.   +9 more
europepmc   +1 more source

Proline reduces brain cytochrome c oxidase: prevention by antioxidants

International Journal of Developmental Neuroscience, 2007
In the present study, we initially investigated the in vivo (acute and chronic) and in vitro effects of proline on cytochrome c oxidase (complex IV) activity in rat cerebral cortex to test the hypothesis that proline might alter energy metabolism and ...
Angela Ts Wyse
exaly   +2 more sources

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Overexpression of proline oxidase induces proline-dependent and mitochondria-mediated apoptosis

Molecular and Cellular Biochemistry, 2006
Proline oxidase (POX), a mitochondrial inner-membrane protein, catalyzes the rate-limiting oxidation of proline to pyrroline- 5-carboxylate (P5C). Previously we showed that overexpression of POX is associated with generation of reactive oxygen species (ROS) and apoptosis in POX-inducible colorectal cancer cells, DLD-1.POX.
Jian Yu, David Valle, Chien-An Hu
exaly   +3 more sources

Regulation and function of proline oxidase under nutrient stress [PDF]

Journal of Cellular Biochemistry, 2009
AbstractUnder conditions of nutrient stress, cells switch to a survival mode catabolizing cellular and tissue constituents for energy. Proline metabolism is especially important in nutrient stress because proline is readily available from the breakdown of extracellular matrix (ECM), and the degradation of proline through the proline cycle initiated by ...
Jui Pandhare
exaly   +3 more sources

Proline dehydrogenase (oxidase) in cancer

BioFactors, 2012
AbstractProline dehydrogenase (oxidase, PRODH/POX), the first enzyme in the proline degradative pathway, plays a special role in tumorigenesis and tumor development. Proline metabolism catalyzed by PRODH/POX is closely linked with the tricarboxylic acid (TCA) cycle and urea cycle.
Wei, Liu, James M, Phang
exaly   +4 more sources

Proline Oxidase (POX) as A Target for Cancer Therapy

Current Drug Targets, 2015
Proline dehydrogenase/proline oxidase (PRODH/POX) is an enzyme catalyzing the first step of proline degradation, during which ROS and/or ATP is generated. POX is widely distributed in living organisms and is responsible for a number of regulatory processes such as redox homeostasis, osmotic adaptation, cell signaling and oxidative stress.
Konończuk, Joanna, Urszula Czyżewska, Moczydłowska, Joanna, Arkadiusz Surażyński, Jerzy Pałka, Wojciech Miltyk   +5 more
openaire   +3 more sources