Results 191 to 200 of about 263,845 (214)
Some of the next articles are maybe not open access.
Expression in Escherichia coli of the Catalytic Domain of Human Proline Oxidase
Protein Expression and Purification, 2012The human PRODH gene has been shown to have unique roles in regulating cell survival and apoptotic pathways and it has been related to velocardiofacial syndrome/DiGeorge syndrome and increased susceptibility to schizophrenia. It encodes for the flavoprotein proline oxidase (PO), which catalyzes the conversion of l-proline to Δ(1)-pyrroline-5 ...
Loredano Pollegioni +2 more
exaly +4 more sources
Identification of a p53-Response Element in the Promoter of the Proline Oxidase Gene
Biochemical and Biophysical Research Communications, 2008Proline oxidase (POX) is a p53-induced proapoptotic gene. We investigated whether p53 could bind directly to the POX gene promoter. Chromatin immunoprecipitation (ChIP) assays detected p53 bound to POX upstream gene sequences. In support of the ChIP results, sequence analysis of the POX gene and its 5' flanking sequences revealed a potential p53 ...
Steve A, Maxwell, Gerald J, Kochevar
exaly +3 more sources
Epoxide derivatives of pipecolic acid and proline are inhibitors of pipecolate oxidase
Bioorganic & Medicinal Chemistry Letters, 1998The cis-4,5-epoxide derivative of L-pipecolic acid (2S,4S,5R-epoxypipecolic acid, cis-3) was synthesized and found to serve as an excellent substrate for L-pipecolate oxidase (L-PO) and also to cause time-dependent, irreversible inactivation of the enzyme. Data are presented showing this compound is a mechanism-based inhibitor of L-PO, whereas 2S,3R,4S-
B, Ho, T M, Zabriskie
openaire +2 more sources
The Journal of Parasitology, 1974
The source was sought for the high levels of proline observed in the bile of animals infected with Fasciola hepatica. Toward this end the activities of 2 key enzymes in the metabolism of proline were measured. Ornithine-4-transaminase was compared in homogenates of Fasciola, rabbit liver, and rat liver.
J, Ertel, H, Isseroff
openaire +2 more sources
The source was sought for the high levels of proline observed in the bile of animals infected with Fasciola hepatica. Toward this end the activities of 2 key enzymes in the metabolism of proline were measured. Ornithine-4-transaminase was compared in homogenates of Fasciola, rabbit liver, and rat liver.
J, Ertel, H, Isseroff
openaire +2 more sources
Acta Physiologiae Plantarum, 1998
Calli of salt tolerant (Bhoora rata) and salt susceptible (GR11) rice varieties were cultured on Linsmaeir and Skoog’s medium containing LD50 concentration of NaCl (200 mM) and hydroxyproline (10 mM). Growth, proline content and activity of proline and IAA oxidases of the cultured tissues were determined at the end of 0, 2, 4, and 6 weeks of incubation.
G Prathapasenan
exaly +2 more sources
Calli of salt tolerant (Bhoora rata) and salt susceptible (GR11) rice varieties were cultured on Linsmaeir and Skoog’s medium containing LD50 concentration of NaCl (200 mM) and hydroxyproline (10 mM). Growth, proline content and activity of proline and IAA oxidases of the cultured tissues were determined at the end of 0, 2, 4, and 6 weeks of incubation.
G Prathapasenan
exaly +2 more sources
Pyrroline-5-Carboxylate Reductase and Proline Oxidase Activity in the Neonatal Pig
The Journal of Nutrition, 1989Recent evidence suggests that proline is an indispensible amino acid in the diet of the young pig. A dietary requirement may relate to the activity and developmental changes of the enzymes that synthesize and degrade proline. The activity of pyrroline-5-carboxylate (P5C) reductase (EC 1.5.1.2), which catalyzes the final step in proline synthesis, and ...
S E, Samuels, K S, Acton, R O, Ball
openaire +2 more sources
Proline reduces brain cytochrome c oxidase: prevention by antioxidants
International Journal of Developmental Neuroscience, 2007Abstract In the present study, we initially investigated the in vivo (acute and chronic) and in vitro effects of proline on cytochrome c ...
Daniela, Delwing +4 more
openaire +2 more sources
A radioisotopic assay for proline oxidase activity.
The Journal of laboratory and clinical medicine, 1975We developed a radioisotopic assay for proline oxidase in which product deltal-pyrroline-5-carboxylate-14-C is reacted with o-aminobenzaldehyde and the radioactivity trapped as the dihydroquinazolinium compound is recovered by ion-exchange chromatography.
J M, Phang +3 more
openaire +1 more source
d-Amino acid oxidase and presence of d-proline in Xenopus laevis
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2013We purified D-amino acid oxidase (EC 1.4.3.3, DAO) from Xenopus laevis tadpoles. The optimal temperature and pH for enzyme activity were 35-40 °C and 8.3-9.0, respectively, depending on the substrate amino acids available to the enzyme; the highest activity was observed with D-proline followed by D-phenylalanine. Activity was significantly inhibited by
Hiroki, Soma +6 more
openaire +2 more sources
Cancer Research, 2012
Abstract A role for reactive oxygen species (ROS) in intracellular signaling has been generally accepted, but the organellar localization, the enzymatic source and the regulation of ROS generation are not well understood. Recent work by others has focused on mitochondria as a source of ROS and specifically on the reduction of oxygen by ...
Chad N. Hancock, James Phang
openaire +1 more source
Abstract A role for reactive oxygen species (ROS) in intracellular signaling has been generally accepted, but the organellar localization, the enzymatic source and the regulation of ROS generation are not well understood. Recent work by others has focused on mitochondria as a source of ROS and specifically on the reduction of oxygen by ...
Chad N. Hancock, James Phang
openaire +1 more source