Results 211 to 220 of about 30,591 (234)
Proline accumulation by mutation or disruption of the proline oxidase gene improves resistance to freezing and desiccation stresses inSaccharomyces cerevisiae [PDF]
FEMS Microbiology Letters, 2000 Hiroshi Takagi +2 more
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Proline oxidase inhibition by free fatty acids of rat pancreas
Biochimica Et Biophysica Acta - Biomembranes, 1980Proline oxidase activity was not measurable in pancreas homogenate but was measurable in pancreas slices. Moreover, added pancreas homogenate inhibited proline oxidase activity in rat liver mitochondria and several other tissues. The partially purified inhibitor from pancreas also inhibited the activity of glutamate, glucose 6-phosphate, NADH and ...
W Eugene Knox, G M Patton
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Expression in Escherichia coli of the catalytic domain of human proline oxidase
Protein Expression and Purification, 2012The human PRODH gene has been shown to have unique roles in regulating cell survival and apoptotic pathways and it has been related to velocardiofacial syndrome/DiGeorge syndrome and increased susceptibility to schizophrenia. It encodes for the flavoprotein proline oxidase (PO), which catalyzes the conversion of l-proline to Δ(1)-pyrroline-5 ...
Loredano Pollegioni +2 more
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Glucocorticoid induction of proline oxidase in LLC‐RK1 cells
Journal of Cellular Physiology, 1978AbstractDexamethasone induced proline oxidase in cultured LLC‐RK1 cells, an epithelial cell line derived from rabbit kidney. The dexamethasone‐mediated increase in enzyme activity was concentration and time dependent. Although the effect could be dissociated from cell growth and cell density, it was dependent on protein and RNA synthesis.
E M, Kowaloff +3 more
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Identification of a p53-response element in the promoter of the proline oxidase gene
Biochemical and Biophysical Research Communications, 2008Proline oxidase (POX) is a p53-induced proapoptotic gene. We investigated whether p53 could bind directly to the POX gene promoter. Chromatin immunoprecipitation (ChIP) assays detected p53 bound to POX upstream gene sequences. In support of the ChIP results, sequence analysis of the POX gene and its 5' flanking sequences revealed a potential p53 ...
Steve A, Maxwell, Gerald J, Kochevar
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Epoxide derivatives of pipecolic acid and proline are inhibitors of pipecolate oxidase
Bioorganic & Medicinal Chemistry Letters, 1998The cis-4,5-epoxide derivative of L-pipecolic acid (2S,4S,5R-epoxypipecolic acid, cis-3) was synthesized and found to serve as an excellent substrate for L-pipecolate oxidase (L-PO) and also to cause time-dependent, irreversible inactivation of the enzyme. Data are presented showing this compound is a mechanism-based inhibitor of L-PO, whereas 2S,3R,4S-
B, Ho, T M, Zabriskie
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The Journal of Parasitology, 1974
The source was sought for the high levels of proline observed in the bile of animals infected with Fasciola hepatica. Toward this end the activities of 2 key enzymes in the metabolism of proline were measured. Ornithine-4-transaminase was compared in homogenates of Fasciola, rabbit liver, and rat liver.
J, Ertel, H, Isseroff
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The source was sought for the high levels of proline observed in the bile of animals infected with Fasciola hepatica. Toward this end the activities of 2 key enzymes in the metabolism of proline were measured. Ornithine-4-transaminase was compared in homogenates of Fasciola, rabbit liver, and rat liver.
J, Ertel, H, Isseroff
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d-Amino acid oxidase and presence of d-proline in Xenopus laevis
Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology, 2013We purified D-amino acid oxidase (EC 1.4.3.3, DAO) from Xenopus laevis tadpoles. The optimal temperature and pH for enzyme activity were 35-40 °C and 8.3-9.0, respectively, depending on the substrate amino acids available to the enzyme; the highest activity was observed with D-proline followed by D-phenylalanine. Activity was significantly inhibited by
Ryo Kaneko +2 more
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Pyrroline-5-Carboxylate Reductase and Proline Oxidase Activity in the Neonatal Pig
The Journal of Nutrition, 1989Recent evidence suggests that proline is an indispensible amino acid in the diet of the young pig. A dietary requirement may relate to the activity and developmental changes of the enzymes that synthesize and degrade proline. The activity of pyrroline-5-carboxylate (P5C) reductase (EC 1.5.1.2), which catalyzes the final step in proline synthesis, and ...
S E, Samuels, K S, Acton, R O, Ball
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Proline reduces brain cytochrome c oxidase: prevention by antioxidants
International Journal of Developmental Neuroscience, 2007AbstractIn the present study, we initially investigated the in vivo (acute and chronic) and in vitro effects of proline on cytochrome c oxidase (complex IV) activity in rat cerebral cortex to test the hypothesis that proline might alter energy metabolism and that this alteration could be provoked by oxidative stress.
Daniela, Delwing +4 more
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