Results 71 to 80 of about 218,823 (239)

Dose-dependent effects of Allopurinol on human foreskin fibroblast cell and human umbilical vein endothelial cell under hypoxia [PDF]

, 2015
Allopurinol, an inhibitor of xanthine oxidase, has been used in clinical trials of patients with cardiovascular and chronic kidney disease. These are two pathologies with extensive links to hypoxia and activation of the transcription factor hypoxia ...
Sun, Yu, George Jacob, Sun Yu, Yu Sun, Sonia Rocha, Jacob George, George, Jacob, Rocha, Sonia, Rocha Sonia   +8 more
core   +1 more source

MnSOD inhibits proline oxidase-induced apoptosis in colorectal cancer cells [PDF]

Carcinogenesis, 2005
Proline oxidase (POX), localized on inner mitochondrial membranes, is encoded by a p53-induced gene and metabolically participates in p53-induced apoptosis. Previously, we showed that POX catalyzed the generation of reactive oxygen species (ROS). We and others have demonstrated that overexpression of POX, independent of p53, causes apoptotic cell death
Liu, Yongmin, Borchert, Gregory, Donald, Steven, Arkadiusz Surażyński, Hu, Chien-An, Weydert, Christine, Oberley, Larry, Phang, James   +7 more
openaire   +2 more sources

Antioxidative system in maize roots as affected by osmotic stress and different nitrogen sources

Biologia Plantarum, 2010
The activities of antioxidative enzymes and contents of proline and total phenolics were assayed in roots of two maize (Zea mays L.) genotypes grown in a medium containing nitrate (NO3 -) or both nitrogen forms, nitrate and ammonium (NH4 +/NO3 -).
M. Vuletić, V. Hadži-Tašković Šukalović, K. Marković, J. Dragišić Maksimović   +3 more
doaj   +1 more source

Potential role of NADPH-oxidase in early steps of lead-induced oxidative burst in Vicia faba roots [PDF]

, 2008
The mechanism of oxidative burst induced by lead in Vicia faba excised roots was investigated by luminol-dependent chemiluminescence. Results showed that lead triggered a rapid and dose-dependent increase in chemiluminescence production.
Perchet, Geoffrey-Thibault, Cecchi, M., Silvestre, Jérôme, Pinelli, Eric, Pourrut, Bertrand, Cecchi, Marie, Guiresse, Agnès Maritchù, Guiresse, Maritxu   +7 more
core   +1 more source

Hyperprolinemia Type IA

Journal of Inborn Errors of Metabolism and Screening, 2017
Objective: Hyperprolinemia type I (HPI) is a rare and inherited autosomal recessive disorder caused by proline oxidase deficiency. Hyperprolinemia type 1 is biochemically defined as high plasma proline levels without urinary Δ-1-pyrroline-5-carboxylate ...
Piero Pavone MD, Andrea D. Praticò MD, Giovanni Sorge MD, Concetta Meli MD, Martino Ruggieri MD, PhD, BA, Renata Rizzo MD, Agata Fiumara MD   +6 more
doaj   +1 more source

Expression and modulation of an NADPH oxidase in mammalian astrocytes [PDF]

, 2005
Amyloid β peptides generate oxidative stress in hippocampal astrocytes through a mechanism sensitive to inhibitors of the NADPH oxidase [diphenylene iodonium (DPI) and apocynin].
Abramov, A.Y., Wientjes, F., Duchen, M.R., Jacobson, J., Canevari, L., Hothersall, J.   +5 more
core  

Evaluating Foliar Application of Calcium Nitrate, Calcium Chloride and Boric Acid on Physiological Disorders of ‘Kaleh - Ghoochi’ Pistachio [PDF]

Journal of Nuts, 2019
Pistachio suffers from some physiological disorders such as fruit abscission, endocarp lesion, blankness, non-split, early-split and deformed nuts. In this experiment, the effects of calcium nitrate (2 gr/lit), calcium chloride (2 gr/lit), boric acid ...
Ebrahim Pourahmadi, Abdorahman Mohamadkhani, Parto Roshandel, Somayeh Momenyan   +3 more
doaj   +1 more source

Hydrogen Sulfide Treatment Alleviates Chilling Injury in Cucumber Fruit by Regulating Antioxidant Capacity, Energy Metabolism and Proline Metabolism

Foods, 2022
Although low-temperature storage could maintain the quality of fruits and vegetables, it may also result in chilling injury (CI) in cold-sensitive produce, such as cucumbers.
Jingda Wang, Yaqin Zhao, Zhiqian Ma, Yonghua Zheng, Peng Jin   +4 more
doaj   +1 more source

Proline accumulation by mutation or disruption of the proline oxidase gene improves resistance to freezing and desiccation stresses inSaccharomyces cerevisiae [PDF]

FEMS Microbiology Letters, 2000
We examined the role of intracellular proline under freezing and desiccation stress conditions in Saccharomyces cerevisiae. When cultured in liquid minimal medium, the proline-nonutilizing mutant containing the put1 mutation (proline oxidase-deficient) produced more intracellular proline, and increased the cell survival rate as compared to the wild ...
H, Takagi, K, Sakai, K, Morida, S, Nakamori   +3 more
openaire   +2 more sources

Immunoinformatics‐Based Design of a Multi‐Epitope Vaccine Targeting a Conserved Copper–Associated Protein in Neisseria gonorrhoeae

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Neisseria gonorrhoeae poses an urgent public health challenge due to rapidly increasing antimicrobial resistance and the absence of an effective vaccine. Targeting conserved bacterial pathways involved in essential physiological processes may provide new opportunities for vaccine antigen discovery.
Sinethemba H. Yakobi, Uchechukwu U. Nwodo   +1 more
wiley   +1 more source