Results 51 to 60 of about 658,113 (299)

The feasibility of prolonged exposure therapy for PTSD in low- and middle-income countries: a review

European Journal of Psychotraumatology, 2020
There is a need in the global south to evaluate and implement empirically supported psychological interventions to ameliorate symptoms of posttraumatic stress disorder (PTSD).
Duane D. Booysen, Ashraf Kagee
doaj   +1 more source

Initial development of perpetrator confrontation using deepfake technology in victims with sexual violence-related PTSD and moral injury

Frontiers in Psychiatry, 2022
BackgroundInterventions aimed at easing negative moral (social) emotions and restoring social bonds – such as amend-making and forgiving—have a prominent role in the treatment of moral injury.
Agnes van Minnen, Agnes van Minnen, F. Jackie June ter Heide, Tilly Koolstra, Ad de Jongh, Ad de Jongh, Sezer Karaoglu, Sezer Karaoglu, Theo Gevers, Theo Gevers   +9 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Therapeutic alliance in intensive PTSD treatment with a therapist rotation model

European Journal of Psychotraumatology
Background: Therapeutic alliance is a robust predictor of treatment outcome. However, little is known about its development and relationship with symptom changes in intensive trauma-focused treatment for post-traumatic stress disorder (PTSD) using a ...
Maryëlle Hoogeveen, Ad De Jongh, Suzy J. M. A. Matthijssen, Eline M. Voorendonk   +3 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

What are the contrindications for prolonged exposure therapy for PTSD; A case report

Psychiatry and Clinical Psychopharmacology, 2021
Although prolonged exposure (PE) has received the most empirical support of any treatment for post-traumatic stress disorder (PTSD), clinicians are often hesitant to use PE due to beliefs that it is contraindicated for many patients with PTSD.
Beyazıt Garip, Adem Balıkçı, Ozcan Uzun, Barbaros Özdemir, Gazi Ünlü, Mehmet Ak   +5 more
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Carboxyhaemoglobin levels and their determinants in older British men [PDF]

, 2006
Background: Although there has been concern about the levels of carbon monoxide exposure, particularly among older people, little is known about COHb levels and their determinants in the general population.
Whincup, Peter, Olia Papacosta, Andrew Haines, Papacosta, O, Peter Whincup, Whincup, P, Papacosta Olia, Lucy Lennon, Whincup Peter, Haines, Andrew, Lennon Lucy, Lennon, Lucy, Lennon, L, Haines, A, Papacosta, Olia, Haines Andrew   +15 more
core   +1 more source