Results 61 to 70 of about 658,113 (299)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Bovine colostrum and immune function after exercise [PDF]

, 2012
Strenuous and/or prolonged exercise causes transient perturbations in immune function. It is well accepted that this is one mechanism contributing to the higher occurrence of infection (e.g.
Glen Davison, Davison, Glen
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Virtual reality for the treatment of posttraumatic disorders

Neuropsychiatric Disease and Treatment, 2016
Thiago Mazzoli Moraes,1 Almir Ferreira de Andrade,2 Wellingson Silva Paiva2,3 1Division of Psychology, 2Division of Neurosurgery, University of São Paulo Medical School, São Paulo, SP, Brazil; 3Neurology Center, Samaritano Hospital,
Moraes T, Andrade A, Paiva W
doaj  

Effectiveness of an intensive treatment programme combining prolonged exposure and eye movement desensitization and reprocessing for severe post-traumatic stress disorder

European Journal of Psychotraumatology, 2018
Background: There is room for improvement regarding the treatment of severe post-traumatic stress disorder (PTSD). Intensifying treatment to increase patient retention is a promising development.
C. Van Woudenberg, E. M. Voorendonk, H. Bongaerts, H. A. Zoet, M. Verhagen, C. W. Lee, A. van Minnen, A. De Jongh   +7 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Threshold limits for biological indication of prolonged radiation exposure using mFISH

, 2014
Chromosome aberration (translocation) yield was investigated by mFISH in peripheral blood lymphocytes of Mayak Production Association (PA) workers with prolonged occupational exposure to ionizing radiation (IR).
Osovets, S., Scherthan, H., Dorr, H., Azizova, T., Sotnik, N., Meineke, V.   +5 more
core   +1 more source

Therapist rotation: a novel approach for implementation of trauma-focused treatment in post-traumatic stress disorder

European Journal of Psychotraumatology, 2018
Background: Trauma-focused treatments (TFTs) for patients with post-traumatic stress disorder (PTSD) are highly effective, yet underused by therapists.Objective: To describe a new way of implementing (adequate use of) TFTs, using a therapist rotation ...
Agnes Van Minnen, Lotte Hendriks, Rianne De Kleine, Gert-Jan Hendriks, Marije Verhagen, Ad De Jongh   +5 more
doaj   +1 more source

Exposure-based treatments for childhood abuse-related post-traumatic stress disorder in adults: a health-economic evaluation

European Journal of Psychotraumatology, 2023
Background: Prolonged exposure (PE) is an effective treatment for post-traumatic stress disorder (PTSD). Objective: This study aimed to analyse the cost-effectiveness of three exposure-based treatments in patients with childhood abuse-related PTSD ...
Marie-Louise J. Kullberg, Maartje Schoorl, Danielle A. C. Oprel, Chris M. Hoeboer, Filip Smit, Willem van der Does, Rianne A. de Kleine, Agnes van Minnen, Wilbert van den Hout   +8 more
doaj   +1 more source

Use of Prolonged Exposure Therapy in Discharge Planning

Health & Social Work, 2021
  Social workers are more than just discharge planners within a hospital setting. In fact, licensed social workers are credentialed to provide therapeutic interventions such as counseling to enhance the discharge planning process. This case study narrative examines prolonged exposure therapy (PE) as an intervention for the discharge of a
openaire   +2 more sources