Results 81 to 90 of about 658,113 (299)

Prolonged allergen exposure induces structural airway changes in sensitized rats

, 2000
The pathogenesis and functional consequences of airway remodeling in asthma remain to be fully established. In the present study we evaluated the effect of prolonged allergen exposure on airway function and structure in rats. Sensitized Brown Norway rats
Kips, Johan, Palmans, Els, ELS PALMANS, JOHAN C. KIPS, ROMAIN A. PAUWELS, Pauwels, Romain   +5 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

The onset of prolonged glare recovery with age

, 1989
The effects of ageing upon the recovery of contrast discrimination following exposure to a bright source of light (glare recovery) were investigated. A total of 65 subjects were tested, with a distribution of ages ranging from 16 to 79 years. Total glare
Michael Collins, Collins, Michael J.
core   +1 more source

Exposing therapists to trauma-focused treatment in psychosis: effects on credibility, expected burden, and harm expectancies

European Journal of Psychotraumatology, 2016
Background: Despite robust empirical support for the efficacy of trauma-focused treatments, the dissemination proves difficult, especially in relation to patients with comorbid psychosis.
David P. G. van den Berg, Berber M. van der Vleugel, Paul A.J.M. de Bont, Gwen Thijssen, Carlijn de Roos, Rianne de Kleine, Tamar Kraan, Helga Ising, Ad de Jongh, Agnes van Minnen, Mark van der Gaag   +10 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Adapting amidst waves: Psychological symptoms and coping in Israeli pandemic [PDF]

Temida
This paper aims to present research findings on psychological symptoms and coping strategies concerning the COVID-19 pandemic in Israel. The aim of the study was to compare distress levels and coping strategies among Israeli citizens during the ...
Shechory Bitton Mally, Laufer Avital
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Prolonged Exposure: An Effective Treatment for PTSD in Military Personnel

, 2014
This paper describes prolonged exposure therapy, an empirically supported treatment for PTSD. The treatment has been applied with success in reducing PTSD symptoms in civilians and military personnel.
Erin Logan, Michael Stevens
core  

A heat acclimation protocol for team sports

, 2008
Background: It is well documented that heat acclimation of 6 or more sessions of at least 60 min duration prolongs the time to exhaustion during endurance walking, cycling and running in the heat. However, this type of acclimation is not specific to team
Sunderland, C, Morris, JG, Nevill, ME
core   +1 more source