Results 61 to 70 of about 468,060 (214)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

A review of ropinirole prolonged release in Parkinson’s disease

open access: yesClinical Interventions in Aging, 2009
Muhammad M Nashatizadeh, Kelly E Lyons, Rajesh PahwaDepartment of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USAAbstract: Ropinirole prolonged release is a once-daily, 24-hour formulation of ropinirole, a non-ergot dopamine ...
Muhammad M Nashatizadeh   +2 more
doaj  

Hydrogel-Based Granular Phytostrengtheners for Prolonged Release: Production and Characterization

open access: yesChemical Engineering Transactions, 2015
Soil wellness is an indispensable requirement to obtain fruits and vegetables with finest quality and with high yields. To the purpose, periodical administrations of nutrients, as well as phytostrengtheners could be required.
D. Caccavo   +5 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

TREATMENT OF EPILEPSY IN CHILDREN: SPECIAL PHARMACEUTICAL FORMS

open access: yesЭпилепсия и пароксизмальные состояния, 2016
treatment of epilepsy in children poses a number of difficulties. This is due to the versatility of epileptic syndromes and epilepsy forms in children and to the problem of age limitations to the use of antiepileptic drugs (AED).
Е. D. Belousova
doaj  

Prolonged Gel Delivery to Oral Cavity from a Silicone Tube: In Vivo Assessment

open access: yesPharmaceutics
Objectives: This study evaluated the comfort of using silicone tubes installed in the oral cavity as a reservoir for a hydrogel that allows for a slow delivery of the active substance acting locally or systemically.
Suhail Alghanem   +4 more
doaj   +1 more source

Biophysical approaches for studying viral entry

open access: yesFEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Long-Acting Gel Formulations: Advancing Drug Delivery across Diverse Therapeutic Areas

open access: yesPharmaceuticals
This multifaceted landscape of long-acting gels in diverse medical fields, aims to enhance therapeutic outcomes through localized treatment and controlled drug release.
Hossein Omidian, Renae L. Wilson
doaj   +1 more source

Dissolution of Intact, Divided and Crushed Circadin Tablets: Prolonged vs. Immediate Release of Melatonin

open access: yesPharmaceutics, 2016
Circadin 2 mg prolonged-release tablet is the only licensed melatonin product available in the UK. Circadin is indicated for patients with primary insomnia aged 55 and over, but is more widely used “off-label” to treat sleep disorders especially in the ...
Hui Ming Chua   +5 more
doaj   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

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