Results 1 to 10 of about 780,037 (214)

Tri-Layer Core–Shell Fibers from Coaxial Electrospinning for a Modified Release of Metronidazole [PDF]

open access: yesPharmaceutics, 2023
Polymers are the backbone of drug delivery. Electrospinning has greatly enriched the strategies that have been explored for developing novel drug delivery systems using polymers during the past two decades. In this study, four different kinds of polymers,
Ying Wang   +5 more
doaj   +2 more sources

Ionotropic Gelation and Chemical Crosslinking as Methods for Fabrication of Modified-Release Gellan Gum-Based Drug Delivery Systems [PDF]

open access: yesPharmaceutics, 2022
Hydrogels have a tridimensional structure. They have the ability to absorb a significant amount of water or other natural or simulated fluids that cause their swelling albeit without losing their structure.
Piotr Gadziński   +9 more
doaj   +2 more sources

Development of a Predictive Flow Through Cell Dissolution Method for Carbamazepine Modified‐Release Tablets [PDF]

open access: yesCPT: Pharmacometrics & Systems Pharmacology
Predictive in vitro dissolution methods are crucial for anticipating in vivo drug performance, particularly for poorly soluble drugs like carbamazepine.
Laura Carvajal Barbosa   +2 more
doaj   +2 more sources

Artificial Neural Networks in Evaluation and Optimization of Modified Release Solid Dosage Forms

open access: yesPharmaceutics, 2012
Implementation of the Quality by Design (QbD) approach in pharmaceutical development has compelled researchers in the pharmaceutical industry to employ Design of Experiments (DoE) as a statistical tool, in product development.
Zorica Djurić   +3 more
doaj   +3 more sources

Comparative effectiveness and prescribing trends of modified release versus immediate release indapamide in patients with hypertension: cohort study [PDF]

open access: yesBMJ Medicine
Objective To investigate the prescribing trends of indapamide, a thiazide-like diuretic, and the long term comparative effectiveness of modified release versus immediate release indapamide.Design Cohort study.Setting IQVIA Medical Research Data UK ...
Li Wei   +9 more
doaj   +2 more sources

Virtual Clinical Trials Guided Design of an Age-Appropriate Formulation and Dosing Strategy of Nifedipine for Paediatric Use

open access: yesPharmaceutics, 2023
The rapid onset of action of nifedipine causes a precipitous reduction in blood pressure leading to adverse effects associated with reflex sympathetic nervous system (SNS) activation, including tachycardia and worsening myocardial and cerebrovascular ...
Dilawar Khan   +5 more
doaj   +1 more source

Dissolution of theophylline from extended-release tablets under cyclic retrograde peristaltic contractions in the Dynamic Colon Model

open access: yesBritish Journal of Pharmacy, 2022
The dynamic colon model isa biorelevant in vitro model of the human proximal colon. In vivo, the large intestine mixes its contents using peristaltic waves that propagate both forwards(antegrade) and backwards (retrograde).
Connor O'Farrell   +3 more
doaj   +1 more source

ARTIFICIAL INTELLIGENCE EVALUATION OF RELEASE PROPERTIES OF TABLET FORMULATION CONTAINING FLURBIPROFEN

open access: yesSabiad, 2023
Objective: The aim of this study was to examine the behavior of two different modified release polymers at different concentrations in terms of their similarity to a commercial product in the market, and to perform optimization studies with these ...
Burcu Mesut, Yavuz Selim Çelik
doaj   +1 more source

Detemplated and Pillared 2-Dimensional Zeolite ZSM-55 with Ferrierite Layer Topology as a Carrier for Drugs

open access: yesMolecules, 2020
The present studies were conducted to show the potential of 2D zeolites as effective and non-toxic carriers of drugs. Layered zeolites exhibit adjustable interlayer porosity which can be exploited for controlled drug delivery allowing detailed ...
Weronika Strzempek   +4 more
doaj   +1 more source

Drug Physicochemical Properties and Capsule Fill Determine Extent of Premature Gastric Release from Enteric Capsules

open access: yesPharmaceutics, 2022
Intrinsically, enteric capsule shells offer several advantages compared to coating of dosage forms with enteric polymers. We undertook a systematic investigation to elucidate capsule-fill parameters that may result in premature gastric drug release from ...
Fouad S. Moghrabi, Hala M. Fadda
doaj   +1 more source

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