Results 21 to 30 of about 2,967 (149)

Identifying Patterns of Clinical Interest in Clinicians’ Treatment Preferences: Hypothesis-free Data Science Approach to Prioritizing Prescribing Outliers for Clinical Review

JMIR Medical Informatics, 2022
BackgroundData analysis is used to identify signals suggestive of variation in treatment choice or clinical outcome. Analyses to date have generally focused on a hypothesis-driven approach. ObjectiveThis study aimed to
Brian MacKenna, Helen J Curtis, Lisa E M Hopcroft, Alex J Walker, Richard Croker, Orla Macdonald, Stephen J W Evans, Peter Inglesby, David Evans, Jessica Morley, Sebastian C J Bacon, Ben Goldacre   +11 more
doaj   +1 more source

Molecular interactions between novel synthesized biodegradable ionic liquids with antidepressant drug

Chemical Thermodynamics and Thermal Analysis, 2021
Biodegradable ionic liquids (BDILs) have immense importance in medicinal chemistry and pharmaceutical industries due to their biodegradable nature. The interaction of antidepressant drug (AD) i.e., promazine hydrochloride (PHC) with novel synthesized ...
Manoj Kumar Banjare, Kamalakanta Behera, Ramesh Kumar Banjare, Siddharth Pandey, Kallol K. Ghosh, Yevgen Karpichev   +5 more
doaj   +1 more source

Characterization of an alkali- and halide-resistant laccase expressed in E. coli: CotA from Bacillus clausii. [PDF]

PLoS ONE, 2014
The limitations of fungal laccases at higher pH and salt concentrations have intensified the search for new extremophilic bacterial laccases. We report the cloning, expression, and characterization of the bacterial cotA from Bacillus clausii, a supposed ...
Søren Brander, Jørn D Mikkelsen, Kasper P Kepp   +2 more
doaj   +1 more source

spectrophotometric Assay of Metoclopramide Hydrochloride in pharmaceutical preparations via oxidative coupling Reaction with proma zine Hydrochloride and N-Bromosuccinimide [PDF]

مجلة التربية والعلم, 2006
Simple, rapid and sensitive spectrophotometric rnethod for the determination of metoclopramide hydrochloride in a bulk sample and in dosage forms is described. The method depends on the oxidative coupling reaction of metoclopramide.
Elham Salih, Intisar Mohamad, Shayma Al-Najafi   +2 more
doaj   +1 more source

Administration Studies in Equine Antidoping Research: Designing Scientific Investigations to Effectively Direct Medication Control in Racehorses. [PDF]

Drug Test Anal
ABSTRACT Pharmacokinetics is the study of the movement of drug in the body and includes the processes of absorption, distribution, metabolism, and excretion. Pharmacodynamics is the pharmacologic effect of the drug on the body. The pharmacokinetics of a drug determines its pharmacologic effect. Pharmacokinetic studies describe drug concentrations while
Knych HK.
europepmc   +2 more sources

Pharmacophore-Based Discovery of Substrates of a Novel Drug/Proton-Antiporter in the Human Brain Endothelial hCMEC/D3 Cell Line

Pharmaceutics, 2022
A drug/proton-antiporter, whose the molecular structure is still unknown, was previously evidenced at the blood-brain barrier (BBB) by functional experiments. The computational method could help in the identification of substrates of this solute carrier (
Maria Smirnova, Laura Goracci, Gabriele Cruciani, Laetitia Federici, Xavier Declèves, Hélène Chapy, Salvatore Cisternino   +6 more
doaj   +1 more source

Copper Single-Atom Catalyst for Efficient C─S Coupling in Thioether Synthesis. [PDF]

Angew Chem Int Ed Engl
We report the first single‐atom catalyst for C─S cross‐coupling, featuring atomically dispersed Cu sites on mesoporous carbon nitride. The catalyst enables efficient, selective, and recyclable thioether synthesis under mild conditions and on a gram scale.
Gazis TA, Palit S, Cipriano LA, Allasia N, Collins SM, Ramasse QM, Kwon IS, Sterrer M, Di Liberto G, Vilé G.   +9 more
europepmc   +3 more sources

Carbocyanine-Based Fluorescent and Colorimetric Sensor Array for the Discrimination of Medicinal Compounds

Chemosensors, 2022
Array-based optical sensing is an efficient technique for the determination and discrimination of small organic molecules. This study is aimed at the development of a simple and rapid strategy for obtaining an optical response from a wide range of low ...
Anna V. Shik, Irina A. Stepanova, Irina A. Doroshenko, Tatyana A. Podrugina, Mikhail K. Beklemishev   +4 more
doaj   +1 more source

Clinicopathological Study of Phytobiotics [PDF]

Benha Veterinary Medical Journal, 2018
This study was carried out to illustrate the effects of phytobiotics (Orego-stim®, promazine plus®) in prevention of coccidiosis in poultry farms and also to examine these effects on some blood biochemical, haematological and immunological parameters in ...
Ali Ali, Ayman S. Farid, Khaled M. Fararh, Nourhan M. Eraky   +3 more
doaj   +1 more source

A Novel Promazine Derivative Shows High in vitro and in vivo Antimicrobial Activity Against Staphylococcus aureus

Frontiers in Microbiology, 2020
The emergence of multidrug-resistant bacteria constitutes a significant public health issue worldwide. Consequently, there is an urgent clinical need for novel treatment solutions.
Troels Ronco, Nadia S. Jørgensen, Iben Holmer, Sofie Kromann, Ehsan Sheikhsamani, Anders Permin, Søren W. Svenningsen, Jørn B. Christensen, Rikke H. Olsen   +8 more
doaj   +1 more source