Results 61 to 70 of about 22,667 (274)

2D non-LTE radiative modelling of He I spectral lines formed in solar prominences

, 2008
The diagnosis of new high-resolution spectropolarimetric observations of solar prominences made in the visible and near-infrared mainly, requires a radiative modelling taking into account for both multi-dimensional geometry and complex atomic models ...
Andretta, Anzer, Asensio Ramos, Benjamin, Benson, Berger, Casini, Centeno, F. Paletou, Fabiani Bendicho, Fernley, Fontenla, Gopalswamy, Gouttebroze, Gouttebroze, Gunár, Heasley, Heasley, Heasley, Heinzel, Heinzel, House, L. Léger, Labrosse, Labrosse, Labrosse, Landi Degl'Innocenti, Lin, Low, Léger, López Ariste, Mauas, Merenda, Paletou, Paletou, Paletou, Paletou, Paletou, Rybicki, Tobiska, Trujillo Bueno, Trujillo Bueno, Trujillo Bueno, Trujillo Bueno, Vial, Vial, Walhstrøm   +46 more
core   +3 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

The Role of Helicity in Magnetic Reconnection: 3D Numerical Simulations

, 1999
We demonstrate that conservation of global helicity plays only a minor role in determining the nature and consequences of magnetic reconnection in the solar atmosphere.
Aly, Aly, Amari, Antiochos, Antiochos, Antiochos, Antiochos, Antiochos, Berger, Dahlburg, Falconer, Gary, Karpen, Karpen, Karpen, Karpen, Klimchuk, Mikić, Moore, Parker, Parker, Priest, Priest, Schmieder, Strauss, Sturrock, Sturrock, Taylor, van Ballegooijen, van Ballegooijen, van Ballegooijen   +30 more
core   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Open questions on prominences from coordinated observations by IRIS, Hinode, SDO/AIA, THEMIS, and the Meudon/MSDP

, 2014
Context. A large prominence was observed on September 24, 2013, for three hours (12:12 UT -15:12 UT) with the newly launched (June 2013) Interface Region Imaging Spectrograph (IRIS), THEMIS (Tenerife), the Hinode Solar Optical Telescope (SOT), the Solar ...
A. López Ariste, B. Schmieder, H. Tian, K. Dalmasse, L. Golub, N. Mein, P. Mein, T. Kucera   +7 more
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Re-visiting the embryogenesis of the human lower lip: An overlooked paradigm

Frontiers in Physiology, 2012
The rare opportunity to study a human fetus showing bilateral clefting of the lower lip along with other associated anomalies resembling those of the equally rare Pena-Shokeir phenotype prompts this report.
Heleni eVastardis, Heleni eVastardis, Meropi N. Spyropoulos, Alphonse R. Burdi   +3 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Tfap2a-dependent changes in mouse facial morphology result in clefting that can be ameliorated by a reduction in Fgf8 gene dosage

Disease Models & Mechanisms, 2015
Failure of facial prominence fusion causes cleft lip and palate (CL/P), a common human birth defect. Several potential mechanisms can be envisioned that would result in CL/P, including failure of prominence growth and/or alignment as well as a failure of
Rebecca M. Green, Weiguo Feng, Tzulip Phang, Jennifer L. Fish, Hong Li, Richard A. Spritz, Ralph S. Marcucio, Joan Hooper, Heather Jamniczky, Benedikt Hallgrímsson, Trevor Williams   +10 more
doaj   +1 more source