Results 111 to 120 of about 1,804,103 (360)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

Characterization of the Promoter Region of the Mouse Gene Encoding the Steroidogenic Acute Regulatory Protein [PDF]

open access: bronze, 1997
Kathleen M. Caron   +5 more
openalex   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Evaluation of different promoters driving the GFP reporter gene in seaweed Kappaphycus alvarezii

open access: yesIndonesian Journal of Biotechnology, 2014
Promoter regulates expression level of foreign gene in transgenic organism. This study was performed to select a suitable promoter as the fi rst step towards production of valuable trait-enhanced seaweed by transgenic technology.
Muh. Alias L. Rajamuddin   +3 more
doaj   +1 more source

Promoter and enhancer RNAs regulate chromatin reorganization and activation of miR-10b/HOXD locus, and neoplastic transformation in glioma

open access: green, 2022
Evgeny Deforzh   +14 more
openalex   +2 more sources

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

Getting promoted [PDF]

open access: yesThe Journal of Thoracic and Cardiovascular Surgery, 2001
Promotion is an active process. At the beginning of his or her academic career, the surgeon should begin planning for this process. Surgeons need to understand the promotion documents at their institutions and to have a timetable for achieving tenure at the appropriate time.
openaire   +2 more sources

The promoter of the operon encoding the F0F1 ATPase of Streptococcus pneumoniae is inducible by pH [PDF]

open access: bronze, 2001
Antonio J. Martín-Galiano   +2 more
openalex   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

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