Results 51 to 60 of about 1,392,700 (321)
Proceedings of the National Academy of Sciences of the United States of America, 2002 The nuclease hypersensitivity element III1 upstream of the P1 promoter of c-MYC controls 85–90% of the transcriptional activation of this gene.
Adam Siddiqui-Jain +3 more
semanticscholar +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
eLife, 2017 Cell differentiation programs require dynamic regulation of gene expression. During meiotic prophase in Saccharomyces cerevisiae, expression of the kinetochore complex subunit Ndc80 is downregulated by a 5’ extended long undecoded NDC80 transcript ...
Minghao Chia +6 more
doaj +1 more source
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma.
Proceedings of the National Academy of Sciences of the United States of America, 1998 Inactivation of the genes involved in DNA mismatch repair is associated with microsatellite instability (MSI) in colorectal cancer. We report that hypermethylation of the 5' CpG island of hMLH1 is found in the majority of sporadic primary colorectal ...
J. Herman +15 more
semanticscholar +1 more source
Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase
FEBS Letters, EarlyView.Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka +6 more
wiley +1 more source
Fitness effects of altering gene expression noise in Saccharomyces cerevisiae
eLife, 2018 Gene expression noise is an evolvable property of biological systems that describes differences in expression among genetically identical cells in the same environment.
Fabien Duveau +7 more
doaj +1 more source
Noise and information transmission in promoters with multiple internal states [PDF]
, 2013 Based on the measurements of noise in gene expression performed during the last decade, it has become customary to think of gene regulation in terms of a two-state model, where the promoter of a gene can stochastically switch between an ON and an OFF state.
arxiv +1 more source
EMBO Journal, 1998 Smad proteins play a key role in the intracellular signalling of transforming growth factor β (TGFβ), which elicits a large variety of cellular responses. Upon TGFβ receptor activation, Smad2 and Smad3 become phosphorylated and form heteromeric complexes
S. Dennler +5 more
semanticscholar +1 more source
FEBS Letters, EarlyView.The glacier ice worm Mesenchytraeus solifugus survives year‐round at 0 °C. Its ATP6 subunit, which forms a regulatory component of the proton pore in mitochondrial ATP synthase, has a carboxy‐terminal extension not found in any other organism examined to date. Here, we show that fusion of this extension to the homologous AtpB protein in E. coli results
Truman Dunkley +2 more
wiley +1 more source
Ecology and SocietyThis research aims to delve into food knowledge and practices concerning the ecological management of food resources, spanning procurement, transformation, and consumption processes, through the lens of creating a cookbook as a tool for decolonizing food
Carolina Gutiérrez Sánchez +5 more
doaj +1 more source