Results 51 to 60 of about 1,403,334 (356)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease

New England Journal of Medicine, 2018
BACKGROUND Given the phenotypic similarities between rheumatoid arthritis (RA)–associated interstitial lung disease (ILD) (hereafter, RA‐ILD) and idiopathic pulmonary fibrosis, we hypothesized that the strongest risk factor for the development of ...
P. Juge, Joyce S. Lee, E. Ebstein, H. Furukawa, E. Dobrinskikh, S. Gazal, C. Kannengiesser, S. Ottaviani, S. Oka, S. Tohma, N. Tsuchiya, J. Rojas-Serrano, M. González-Pérez, M. Mejía, I. Buendía-Roldán, R. Falfán-Valencia, E. Ambrocio-Ortiz, E. Manali, S. Papiris, T. Karageorgas, D. Boumpas, K. Antoniou, C. V. van Moorsel, J. J. van der Vis, Y. D. de Man, J. Grutters, Yaping Wang, R. Borie, L. Wémeau-Stervinou, B. Wallaert, R. Flipo, H. Nunes, D. Valeyre, N. Saidenberg-Kermanac’h, M. Boissier, S. Marchand-Adam, A. Frazier, P. Richette, Y. Allanore, J. Sibilia, C. Dromer, C. Richez, T. Schaeverbeke, H. Lioté, G. Thabut, N. Nathan, S. Amselem, M. Soubrier, V. Cottin, A. Clément, K. Deane, A. Walts, T. Fingerlin, A. Fischer, J. Ryu, E. Matteson, T. Niewold, D. Assayag, A. Gross, P. Wolters, M. Schwarz, M. Holers, J. Solomon, T. Doyle, I. Rosas, C. Blauwendraat, M. Nalls, M. Debray, C. Boileau, B. Crestani, D. Schwartz, P. Dieudé   +71 more
semanticscholar   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Living community cookbook: transdisciplinary collaboration for constructing recipes with biocultural value

Ecology and Society
This research aims to delve into food knowledge and practices concerning the ecological management of food resources, spanning procurement, transformation, and consumption processes, through the lens of creating a cookbook as a tool for decolonizing food
Carolina Gutiérrez Sánchez, Claudia Leyva Aguilera, Rebeca Moreno-Santoyo, Lorena Pedrín Rivera, Sandra Montes Carrillo, Lluvia Dorantes Herrera   +5 more
doaj   +1 more source

Identification of a differentially expressed gene, ACL, between Meishan × Large White and Large White × Meishan F1 hybrids and their parents

Genetics Selection Evolution, 2008
ATP-citrate lyase (ACL), one of the lipogenic enzymes, catalyses the formation of acetyl-coenzyme A (CoA) involved in the synthesis of fatty acid and cholesterol. In pig, very little is known about the ACL gene.
Xiong Yuan-Zhua, Jiang Si-Wen, Deng Chang-Yan, Zheng Rong, Xu De-Quan, Li Feng-E, Zuo Bo, Lei Ming-Gang, Wang Lin-Jie, Xu Yong-Jie, Wang Yan, Ren Zhu-Qing   +11 more
doaj   +1 more source

Molecular Mechanism of Mesenchyme Homeobox 1 in Transforming Growth Factor β1–Induced P311 Gene Transcription in Fibrosis

Frontiers in Molecular Biosciences, 2020
Organ fibrosis is characterized by excessive fibroblast, and extracellular matrix and the molecular basis are not fully elucidated. Recent studies have proven that P311, an 8-kDa conserved protein, could promote various organ fibrosis, such as skin ...
Zhiyuan Wei, Chao Han, Haisheng Li, Weifeng He, Junyi Zhou, Hui Dong, Yuzhang Wu, Yi Tian, Gaoxing Luo   +8 more
doaj   +1 more source

Characterizing Promoter and Enhancer Sequences by a Deep Learning Method

Frontiers in Genetics, 2021
Promoters and enhancers are well-known regulatory elements modulating gene expression. As confirmed by high-throughput sequencing technologies, these regulatory elements are bidirectionally transcribed. That is, promoters produce stable mRNA in the sense
Xin Zeng, Sung-Joon Park, Kenta Nakai, Kenta Nakai   +3 more
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Functional Characterization of a Dual Enhancer/Promoter Regulatory Element Leading Human CD69 Expression

Frontiers in Genetics, 2020
The CD69 gene encodes a C-type lectin glycoprotein with immune regulatory properties which is expressed on the cell surfaces of all activated hematopoietic cells.
Jennifer Redondo-Antón, MG Fontela, Laura Notario, Raúl Torres-Ruiz, Sandra Rodríguez-Perales, Elena Lorente, Pilar Lauzurica   +6 more
doaj   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source