An investigation of herpes simplex virus promoter activity compatible with latency establishment reveals VP16-independent activation of immediate-early promoters in sensory neurones [PDF]
, 2011 Herpes simplex virus (HSV) type-1 establishes lifelong latency in sensory neurones and it is widely assumed that latency is the consequence of a failure to initiate virus immediate-early (IE) gene expression. However, using a Ore reporter mouse system in
Arthur, J. +6 more
core +1 more source
TERT Promoter Mutations and Risk of Recurrence in Meningioma.
Journal of the National Cancer Institute, 2016 The World Health Organization (WHO) classification and grading system attempts to predict the clinical course of meningiomas based on morphological parameters.
F. Sahm +32 more
semanticscholar +1 more source
The Generation of Promoter-Mediated Transcriptional Noise in Bacteria [PDF]
Plos. Comp. Biol. 4, e1000109 (2008), 2008 Noise in the expression of a gene produces fluctuations in the concentration of the gene product. These fluctuations can interfere with optimal function or can be exploited to generate beneficial diversity between cells; gene expression noise is therefore expected to be subject to evolutionary pressure.
arxiv +1 more source
The RNA Polymerase II Core Promoter in Drosophila. [PDF]
, 2019 Transcription by RNA polymerase II initiates at the core promoter, which is sometimes referred to as the "gateway to transcription." Here, we describe the properties of the RNA polymerase II core promoter in Drosophila The core promoter is at a strategic
Kadonaga, James T +2 more
core +1 more source
Prediction of Prokaryotic and Eukaryotic Promoters Using Convolutional Deep Learning Neural Networks [PDF]
arXiv, 2016 Accurate computational identification of promoters remains a challenge as these key DNA regulatory regions have variable structures composed of functional motifs that provide gene specific initiation of transcription. In this paper we utilize Convolutional Neural Networks (CNN) to analyze sequence characteristics of prokaryotic and eukaryotic promoters
arxiv
Dynamical Analysis on Gene Activity in the Presence of Repressors and an Interfering Promoter [PDF]
, 2008 Transcription is regulated through interplay between transcription factors, an RNA polymerase(RNAP), and a promoter. Even for a simple repressive transcription factor that disturbs promoter activity at the initial binding of RNAP, its repression level is not determined solely by the dissociation constant of transcription factor but is sensitive to the ...
arxiv +1 more source
Studia Universitatis Babeş-Bolyai. Musica, 2013 Although identifying and defining texture as a specific sound organization in sound mass compositions comes about frequently in contemporary musicology, only a handful of researchers regard this as a tendency of what turns out to be a large number of ...
Andrei C. COZMA
doaj
Activation of Egr-1 expression in astrocytes by HIV-1 Tat: new insights into astrocyte-mediated Tat neurotoxicity [PDF]
, 2011 Human immunodeficiency virus type 1 (HIV-1) Tat plays an important role in HIV-associated neuropathogenesis; the underlying mechanisms are still evolving. We have recently shown that HIV-1 Tat induces expression of glial fibrillary acidic protein (GFAP),
Fan, Yan +4 more
core +1 more source
Promotion on Generalized Oscillating Tableaux and Web Rotation [PDF]
arXiv, 2017 We introduce the notion of a generalized oscillating tableau and define a promotion operation on such tableaux that generalizes the classical promotion operation on standard Young tableaux. As our main application, we show that this promotion corresponds to rotation of the irreducible $A_2$-webs of G. Kuperberg.
arxiv
CRISPR-dCas9 mediated TET1 targeting for selective DNA demethylation at BRCA1 promoter
OncoTarget, 2016 DNA hypermethylation at the promoter of tumour-suppressor genes is tightly correlated with their transcriptional repression and recognized as the hallmark of majority of cancers.
S. R. Choudhury +4 more
semanticscholar +1 more source