Results 261 to 270 of about 556,506 (299)

Methylation of the telomerase gene promoter region in umbilical cord blood of patients with gestational diabetes mellitus is associated with decreased telomerase expression levels and shortened telomere length. [PDF]

Front Endocrinol (Lausanne)
Liu S, Xu L, Cheng Y, Liu D, Zhang B, Chen X, Zheng M.   +6 more
europepmc   +1 more source

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Genetic polymorphisms in the promoter region of interleukin-8

International Congress Series, 2003
Abstract In septic patients, local and systemic production of interleukin-8 (IL-8) is augmented, and we and other researchers have previously shown that serum IL-8 levels predict the development of multiple organ dysfunction syndrome (MODS) and poor prognosis. There is a wide variation in IL-8 levels among septic patients under similar conditions and
Naoki Aikawa, Seitaro Fujishima, Sadakazu Aiso, Katsunori Aoki, Shingo Hori   +4 more
openaire   +2 more sources

Isolation and Genetic Localization of Three ϕX174 Promoter Regions

Nature New Biology, 1973
SPECIFIC sequences of nucleic acids such as ribosome binding sites1 (W. Gilbert, cited in ref. 2) and portions of the promoter region3,4 have been isolated by protecting those sequences with the relevant protein or organelle and digesting away the exposed nucleic acid. We have isolated specific sequences from the promoter regions in bacteriophage ϕX174
Clyde A. Hutchison, Cheng-Yien Chen, Marshall Hall Edgel   +2 more
openaire   +3 more sources

A Genetic Polymorphism in the Promoter Region of DRD4 Associated with Expression and Schizophrenia

Biochemical and Biophysical Research Communications, 1999
The human dopamine D4 receptor gene (DRD4) is an important candidate gene for schizophrenia. We identified a novel -521C>T polymorphism in the 5'-promoter region of DRD4. A transient expression method revealed that the T allele of this polymorphism reduces the transcriptional efficiency by 40% compared with the C allele.
Yuki Okuyama, Michio Toru, Hiroki Ishiguro, Tadao Arinami   +3 more
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Identification of the promoter region and genetic mutations of the porcine GALP gene

Molecular Biology Reports, 2012
Galanin-like peptide (GALP) gene, encoding a member of the galanin family of neuropeptides involved in reproduction, was differentially expressed in PMSG-hCG stimulated pre-ovulatory ovarian follicles of Chinese Taihu and Large White sows in our previous study.
Xiaojie Sun, Lina Su, Fenge Li, Xuying Zhang, Qiao Mu, Shuqi Mei, Hua-Yu Wu, Hu Tao, Xianwen Peng   +8 more
openaire   +3 more sources

Genetic variation in the promoter region of the basic fibroblast growth factor gene

Human Immunology, 2003
Basic fibroblast growth factor (bFGF) is a member of the fibroblast growth factor family that possess broad mitogenic and cell survival activities and is involved in a variety of biological processes. We investigated possible genetic polymorphism in the promoter and 5' flanking region of the bFGF gene. Polymorphism was analysed by means of heteroduplex
Kateřina Kaňková, J.iří Vácha, Svatava Tschöplová, Michal Beránek, V.ěra Kuhrová   +4 more
openaire   +3 more sources

Genetic Polymorphism in the Serotonin Transporter Promoter Region and Ecological Success in Macaques

Behavior Genetics, 2010
A well-characterised sequence length polymorphism in the serotonin transporter promoter region (5-HTTLPR) influences individual behavioural traits and cognitive abilities in humans and rhesus macaques. Macaques have been classified into four continuous grades on the basis of their behavioural attributes, ranging from highly hierarchical and nepotistic ...
Uma Ramakrishnan, Subhankar Chakraborty, Subhankar Chakraborty, Debapriyo Chakraborty, Debapriyo Chakraborty, Debapriyo Chakraborty, Odity Mukherjee, Odity Mukherjee, Sanjeev Jain, Sanjeev Jain, Anindya Sinha, Anindya Sinha   +11 more
openaire   +3 more sources

Identification and genetic effect of haplotypes in the promoter region of porcine myostatin gene

Animal Genetics, 2011
Myostatin plays a pivotal role in controlling skeletal muscle mass in mammals. Polymorphisms in its promoter region likely impact on transcription and production traits. In this study, haplotypes involving three polymorphic sites in the promoter region of the porcine myostatin gene, namely at sites 435, 447 and 879, were identified and their effect on ...
Y. Wu, Yunliang Jiang, Q. Xu, S. Wei, Suyun Liang, L. Zang, Dapeng Liu   +6 more
openaire   +3 more sources

Functional Characterization of Genetic Polymorphisms Identified in the Promoter Region of the Xanthine Oxidase Gene

Drug Metabolism and Pharmacokinetics, 2010
Xanthine oxidase (XO) catalyzes the oxidation of endogenous and exogenous purines and pyrimidines. In the present study, we investigated polymorphisms in the promoter region of the XO gene. Sequence variations in the 5'-flanking region were screened using denaturing high-performance liquid chromatography (DHPLC) on DNA samples from 196 unrelated ...
Masaaki Ishikawa, Mutsumi Kudo, Takamitsu Sasaki, Noriyasu Hirasawa, Masahiro Hiratsuka   +4 more
openaire   +3 more sources

Genetic analysis of the TBX20 gene promoter region in patients with ventricular septal defects

Gene, 2012
Congenital heart disease (CHD) is the most common human birth defect. The morbidity and mortality of CHD patients are significantly higher than normal population even after surgical correction of cardiac defects, which is likely caused by genetic defects. To date, genetic causes for CHD remain largely unknown.
Jiping Shan, Hongxin Wanyan, Shuchao Pang, Bo Yan, Qining Xing, Wen Xie, Yanli Qiao   +6 more
openaire   +3 more sources