Results 291 to 300 of about 795,608 (343)

Identification and genetic effect of haplotypes in the promoter region of porcine myostatin gene

Animal Genetics, 2011
Myostatin plays a pivotal role in controlling skeletal muscle mass in mammals. Polymorphisms in its promoter region likely impact on transcription and production traits. In this study, haplotypes involving three polymorphic sites in the promoter region of the porcine myostatin gene, namely at sites 435, 447 and 879, were identified and their effect on ...
Y. Wu, Yunliang Jiang, Q. Xu, S. Wei, Suyun Liang, L. Zang, Dapeng Liu   +6 more
openaire   +3 more sources

Genetic analysis of the TBX20 gene promoter region in patients with ventricular septal defects

Gene, 2012
Congenital heart disease (CHD) is the most common human birth defect. The morbidity and mortality of CHD patients are significantly higher than normal population even after surgical correction of cardiac defects, which is likely caused by genetic defects. To date, genetic causes for CHD remain largely unknown.
Jiping Shan, Hongxin Wanyan, Shuchao Pang, Bo Yan, Qining Xing, Wen Xie, Yanli Qiao   +6 more
openaire   +3 more sources

Functional Characterization of Genetic Polymorphisms Identified in the Promoter Region of the Xanthine Oxidase Gene

Drug Metabolism and Pharmacokinetics, 2010
Xanthine oxidase (XO) catalyzes the oxidation of endogenous and exogenous purines and pyrimidines. In the present study, we investigated polymorphisms in the promoter region of the XO gene. Sequence variations in the 5'-flanking region were screened using denaturing high-performance liquid chromatography (DHPLC) on DNA samples from 196 unrelated ...
Masaaki Ishikawa, Mutsumi Kudo, Takamitsu Sasaki, Noriyasu Hirasawa, Masahiro Hiratsuka   +4 more
openaire   +3 more sources

Genetic Variants in the Promoter Region of the IGF-I Gene as a Reason for Short Stature

Journal of Pediatric Endocrinology and Metabolism, 2006
DNA obtained from the blood cells of 88 adolescent patients with short stature, with low blood serum IGF-I concentrations, normal growth hormone (GH) secretion and normal GH receptor (GHR) structure, was analyzed in the promoter region for the IGF-I gene. A total of 24 genetic variants was detected in the DNA of 13 patients. An attempt was also made to
Monika Obara-Moszynska, A Goździcka-Józefiak, Eugeniusz Korman, Aleksandra Obrępalska-Stęplowska, J Pacholska-Bogalska, Andrzej Kędzia   +5 more
openaire   +3 more sources

Genetic analysis of the promoter region of the GATA4 gene in patients with ventricular septal defects

Translational Research, 2012
Ventricular septal defects (VSDs) are the most common type of congenital heart diseases (CHDs). To date, the genetic causes for sporadic VSDs remain largely unknown. GATA transcription factor 4 (GATA4) is a zinc-finger transcription factor that is expressed in developing heart and adult cardiomyocytes.
Bo Yan, Shuchao Pang, Jiping Shan, Guanghua Wu, Xiaodan Wei, Hao Zhang   +5 more
openaire   +3 more sources

A genetic variant in the promoter region of miR-877 is associated with an increased risk of hepatocellular carcinoma

Clinics and Research in Hepatology and Gastroenterology, 2020
Genome wide association study has identified chromosome 6p21.33 as a risk locus of hepatocellular carcinoma (HCC). MiR-877 is located on this region, functioning as a tumor suppressor. The aim of this study was to investigate the association between rs1264440 in the promoter of miR-877 and HCC risk.A total of 352 HCC patients and 359 age, gender ...
Ruixuan Fan, Tao Wang, Hongtu Wang, Bo Wang   +3 more
openaire   +3 more sources

Genetic analysis of regulatory, promoter, and TAR regions of LTR sequences belonging to HIV type 1 Non-B subtypes.

AIDS Research and Human Retroviruses, 2005
Transcriptional activation of HIV-1 gene expression is controlled by the interaction of sequence-specific transcription factors with the long terminal repeat (LTR).
Eva Ramírez de Arellano, V. Soriano, Á. Holguín   +2 more
semanticscholar   +1 more source

Identification and genetic effects of a novel polymorphism in the distal promoter region of porcine leptin gene

Molecular Biology Reports, 2010
Leptin is a hormone expressed mainly in white adipose tissue. It acts on satiety centers in the hypothalamus, and by binding to particular receptor OB-Rb, plays a crucial role in controlling appetite, body weight, fat amount and total energy balance. In this study, a novel single nucleotide polymorphism (SNP), i.e., SNP G-2863A, was identified in the ...
Shudong Wei, Yunliang Jiang, Xiaohui Yang, Yue Hu, Dongjun Liu, Yuan Liu   +5 more
openaire   +2 more sources

A Genetic Variant in the Promoter Region of Toll-Like Receptor 9 and Cervical Cancer Susceptibility

DNA and Cell Biology, 2012
The Toll-like receptors (TLRs) are important for the innate immune system by recognizing pathogen-associated molecular patterns expressed in infectious agents. E6 and E7 protein from HPV16 suppress the host immune response by regulating the TLR9 transcript.
Li Liu, Yanjing Kan, Yan Shen, Sumin Wang, Zhibin Hu, Fulin Qiang, Zengyan Chen, Xiaojun Chen, Hongbing Shen, Jiangping Wu   +9 more
openaire   +3 more sources

Highly specific localization of promoter regions in large genomic sequences by PromoterInspector: a novel context analysis approach.

Journal of Molecular Biology, 2000
We present a new algorithm called PromoterInspector to locate eukaryotic polymase II promoter regions in large genomic sequences with a high degree of specificity.
Matthias Scherf, A. Klingenhoff, Thomas Werner   +2 more
semanticscholar   +1 more source