Results 221 to 230 of about 466,642 (309)

Cohesin acts as a transcriptional gatekeeper by restraining pause-release to promote processive elongation. [PDF]

Nat Commun
Tei S, Bando M, Sakata T, Yoshimura A, Natsume T, Kanemaki MT, Sutani T, Shirahige K.   +7 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Type I restriction-modification systems regulate gene expression through DNA topology. [PDF]

Nucleic Acids Res
Althari Y, Chen YK, Menon A, Ferrándiz MJ, van Raaphorst R, De Ste Croix M, Ulijasz AT, Glanville DG, Veening JW, Bentley SD, Croucher NJ, Bayliss CD, de la Campa AG, Zhang JR, Trappetti C, Haigh RD, Oggioni MR.   +16 more
europepmc   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

A plant DNMT3 induces non-CG methylation and affects gene expression in human cells. [PDF]

iScience
Domb R, Heskiau KG, Katz A, Yaari R, Zamostiano R, Harris KD, Bacharach E, Ohad N, Zemach A.   +8 more
europepmc   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Cis- and trans-regulatory factors contributing to divergent activity of the TDH3 promoter in Saccharomyces yeast. [PDF]

Mol Biol Evol
Siddiq MA, Kania HP, Brown NJ, Wittkopp PJ.   +3 more
europepmc   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Expanding the Genetic Toolkit of Pichia kudriavzevii E1 for Enhanced Mycoprotein Production. [PDF]

Microb Biotechnol
Wang Y, Gao S, Wu C, Guo L, Han P, Wang L, Ruchała J, Yu B.   +7 more
europepmc   +1 more source