Results 121 to 130 of about 1,649,150 (304)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Predicting Work Motivation Through Job Satisfaction and Turnover Intentions: The Explanatory Role of Heavy Work Investment

The Lahore Journal of Business, 2015
This study investigates the relationship among job attitudes (job satisfaction and turnover intentions), heavy work investment (work engagement and workaholism), and work motivation (promotion focus and prevention focus).
Ishfaq Ahmed, Muhammad Khalid Khan
doaj  

May I continue or should I stop? the effects of regulatory focus and message framings on video game players’ self-control [PDF]

Two types of motivations exist in terms of regulatory focus: a promotion orientation concerned with advancement and achievement and a prevention orientation concerned with safety and security.
Ho, Shu-Hsun, Lin, Chia-Yin, Putthiwanit, Chutinon   +2 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Asymmetric perception of gains vs non-losses and losses vs non-gains: The causal role of regulatory focus [PDF]

Recent studies show that, while losses loom larger than equivalent non-gains, gains loom larger than equivalent non-losses. This finding, at odds with the loss aversion principle, has been interpreted within the framework of regulatory focus theory.
Luca Stanca, Simona Sacchi
core  

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

The effect of parental regulatory focus on the loneliness stigma of college children

BMC Public Health
Background The present study aimed to examine the relationship between regulatory focus and loneliness stigma, as well as the intergenerational transmission of the two.
Zhiguang Fan, Xiaoli Shi, Wei Zhang, Bin Zhang   +3 more
doaj   +1 more source

AMIRIS - Agent based model for the integration of renewables into the electricity markets [PDF]

, 2013
The model AMIRIS allows the evaluation of political instruments and promotion mechanisms regarding their impact on actors‘ behaviours and development of the energy system.
Deissenroth, Marc, Kristina, Nienhaus, Matthias, Reeg   +2 more
core  

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source