Results 31 to 40 of about 19,650 (268)

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

The Impact of Tenapanor on Body Composition and Blood Pressure in Peritoneal Dialysis Patients: A Pilot Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Instruction Tenapanor potentially affects fluid volume and blood pressure. This study explored its effects on these parameters in patients undergoing peritoneal dialysis (PD). Methods We conducted a single‐arm, prospective observational study that enrolled 10 patients on PD with hyperphosphatemia who were newly initiated on tenapanor.
Shun Yoshida, Kengo Asahina, Keiichi Osano, Natsumi Saegusa, Kohei Yamamura, Kie Ohkoshi, Miho Shikata, Toshihisa Ishii, Makiko Konishi, Kazuya Takahashi, Kohei Uchimura, Ayumu Nakashima   +11 more
wiley   +1 more source

Efeito a curto prazo da posição prona na oxigenação de crianças em ventilação mecânica Short-term effects of prone positioning on the oxygenation of pediatric patients submitted to mechanical ventilation

Jornal de Pediatria, 2001
OBJETIVOS: analisar o efeito a curto prazo da posição prona na oxigenação de pacientes pediátricos com hipoxemia severa e submetidos à ventilação mecânica. MATERIAL E MÉTODOS: ensaio clínico prospectivo, não randomizado, sendo cada paciente o seu próprio
Francisco Bruno, Jefferson P Piva, Pedro Celiny R. Garcia, Paulo Einloft, Renato Fiori, Sérgio Menna Barreto   +5 more
doaj   +1 more source

The Effect of Systematic Corrective Exercises on the Ankle Proprioception in People with Functional Pronation Distortion Syndrome: A Randomized Controlled Clinical Trial Study

مجله پژوهش در علوم توانبخشی, 2020
Introduction: Pronation distortion syndrome is one of the most common abnormalities in the lower extremity that causes distortions in the structures of the skeletal parts of the foot.
Ali Golchini, Nader Rahnama
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The Study of Static Lower Extremity Alignment in Female Athletes with ACL Injury [PDF]

Sport Sciences and Health Research, 2009
The aim of the present study was to investigate three important mal-alignments (pronation, tibial torsion and Q angle) as risk factors in ACL tear in professional female athletes. Twenty ACL – injured females (age 24.90 ? 5.75 years, height 167.05 ? 6.58
hasan daneshmandi, farzane saki
doaj  

Biomechanical assessment of brachioradialis pronatorplasty

Acta Orthopaedica et Traumatologica Turcica, 2020
Objective: Transfer of the brachioradialis muscle, proposed by Özkan et al. can be applied to cases, in which, the biceps rerouting technique is not appropriate for the correction of forearm supination contracture and restoration of active pronation.
Halil İbrahim Bekler, Turker Ozkan
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source