Results 41 to 50 of about 19,650 (268)

The Acute Effect of Using Anti-pronation Insoles on Muscle Frequency Content in an Individual with Anterior Cruciate Ligament Reconstruction and Pronated Feet during Running(Original Article) [PDF]

open access: yesJournal of Ardabil University of Medical Sciences, 2023
Background: Anterior cruciate ligament reconstruction (ACLR) reestablishes electromyography activity during moderate activities such as walking but it is unclear whether this is also the case in sports activities such as running.
Raziye Alizadeh   +2 more
doaj  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

Which pronator are you? New perspectives from an unsupervised clustering approach in running

open access: yesFrontiers in Sports and Active Living
Introduction: Excessive pronation is still considered as a factor partially involved in the running-related injury risk despite inconsistent evidence. The between-runner variability and the way excessive pronation is quantified are potentially involved ...
Nicolas Flores, Cédric Yves-Marie Morio
doaj   +1 more source

Should Diastatic Syndesmosis be Stabilized in Advanced Pronation‐External Rotation Ankle Injuries? A Retrospective Cohort Comparison

open access: yesOrthopaedic Surgery, 2022
Objective With or without screw stabilization for diastatic syndesmosis in advanced pronation‐external rotation (PE) ankle injuries has not yet been well‐determined.
Chi‐chuan Wu   +5 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Foot Pronation Contributes to Altered Lower Extremity Loading After Long Distance Running

open access: yesFrontiers in Physiology, 2019
This study presents an investigation of the changes in foot posture, joint kinematics, joint moments and joint contact forces in the lower extremity following a 5 k treadmill run. A relationship between knee and ankle joint loading and foot posture index
Qichang Mei   +12 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

open access: yesFEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda   +2 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

open access: yesFEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis   +2 more
wiley   +1 more source

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