Results 51 to 60 of about 24,157 (301)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Foot Pronation Contributes to Altered Lower Extremity Loading After Long Distance Running

Frontiers in Physiology, 2019
This study presents an investigation of the changes in foot posture, joint kinematics, joint moments and joint contact forces in the lower extremity following a 5 k treadmill run. A relationship between knee and ankle joint loading and foot posture index
Qichang Mei, Qichang Mei, Qichang Mei, Yaodong Gu, Yaodong Gu, Yaodong Gu, Liangliang Xiang, Liangliang Xiang, Julien S. Baker, Julien S. Baker, Justin Fernandez, Justin Fernandez, Justin Fernandez   +12 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

A Multi-modal Strategy to Activate Pronation for Acute Respiratory Distress Syndrome Patients [PDF]

, 2022
Background: Acute Respiratory Distress Syndrome (ARDS) is an acute pulmonary process that compromises the health of patients in the Intensive Care Unit (ICU).
McCrorie, Meredith
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Anconeus and pronation: a palpatory and ultrasonographic study.

Purpose Depending on its axis, pronation varies from the radius rotation around the steady ulna to the reciprocal adduction of the radius and abduction of the ulna. While there is no question that pronator teres is a central pronation agonist, anconeus’s
García Carpintero Blas, Eva, Naredo, Esperanza, Kalish, Robert A., Fuensalida Novo, Gema, Canoso, Juan J., Murillo González, Jorge Alfonso, Olivas Vergara, Otto, Mérida Velasco, José Ramón, Gómez Moreno, Cristina   +8 more
core   +1 more source

Finite Element Analysis of Generalized Ligament Laxity on the Deterioration of Hallux Valgus Deformity (Bunion)

Frontiers in Bioengineering and Biotechnology, 2020
Hallux valgus is a common foot problem affecting nearly one in every four adults. Generalized ligament laxity was proposed as the intrinsic cause or risk factor toward the development of the deformity which was difficult to be investigated by cohort ...
Duo Wai-Chi Wong, Duo Wai-Chi Wong, Yan Wang, Yan Wang, Tony Lin-Wei Chen, Fei Yan, Yinghu Peng, Qitao Tan, Ming Ni, Aaron Kam-Lun Leung, Ming Zhang, Ming Zhang   +11 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The Effects of 12 Weeks of Systematic and Functional Corrective Exercises on Body Posture of Students Suffering From Pronation Distortion Syndrome

Iranian Rehabilitation Journal, 2020
Objectives: Pronation distortion syndrome is one of the common physical deformities, that causes distortions in the skeletal structures of the feet. The current study aimed to determine the effects of 12 weeks of systematic and functional corrective ...
Ali Golchini, Nader Rahnama
doaj  

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source