Results 51 to 60 of about 19,650 (268)

Finite Element Analysis of Generalized Ligament Laxity on the Deterioration of Hallux Valgus Deformity (Bunion)

Frontiers in Bioengineering and Biotechnology, 2020
Hallux valgus is a common foot problem affecting nearly one in every four adults. Generalized ligament laxity was proposed as the intrinsic cause or risk factor toward the development of the deformity which was difficult to be investigated by cohort ...
Duo Wai-Chi Wong, Duo Wai-Chi Wong, Yan Wang, Yan Wang, Tony Lin-Wei Chen, Fei Yan, Yinghu Peng, Qitao Tan, Ming Ni, Aaron Kam-Lun Leung, Ming Zhang, Ming Zhang   +11 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

The Effects of 12 Weeks of Systematic and Functional Corrective Exercises on Body Posture of Students Suffering From Pronation Distortion Syndrome

Iranian Rehabilitation Journal, 2020
Objectives: Pronation distortion syndrome is one of the common physical deformities, that causes distortions in the skeletal structures of the feet. The current study aimed to determine the effects of 12 weeks of systematic and functional corrective ...
Ali Golchini, Nader Rahnama
doaj  

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Comparison of Two Different Kinesiotaping Techniques on Moderate to Severe Hallux Valgus: A Pilot StudyComparison of Two Different Kinesiotaping Techniques on Moderate to Severe Hallux Valgus: A Pilot Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Moderate to severe hallux valgus causes pain in the foot, balance deficits, gait impairments and eventually falls. With a chronic progressive onset the severity of hallux valgus increases. Regular kinesiotaping delivered will not be able to
Amita Aggarwal, Apoorva Nale, Shardul Sutar   +2 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Effect of Fatigue on Mechanical Values of Impulse and Center of Pressure in Obese Male Students with Pronated Feet During a Landing Maneuver [PDF]

مجله دانشگاه علوم پزشکی گرگان
Background and Objective: Obesity is a major public health concern worldwide. Evidence suggests that fatigue can lead to significant alterations in mechanical components among obese individuals compared to their healthy counterparts.
Amir Ali Jafarnezhadgero, Ehsan Fakhri Mirzanag, Farhad Rezazadeh   +2 more
doaj  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source